PUBLICATION
Vitellogenin is an acute phase protein with bacterial-binding and inhibiting activities
- Authors
- Tong, Z., Li, L., Pawar, R., and Zhang, S.
- ID
- ZDB-PUB-091221-6
- Date
- 2010
- Source
- Immunobiology 215(11): 898-902 (Journal)
- Registered Authors
- Li, Lei
- Keywords
- Zebrafish, Danio rerio, Vitellogenin, Acute phase response, Antibacterial activity
- MeSH Terms
-
- Animals
- Escherichia coli/immunology*
- Female
- Lipopolysaccharides/immunology
- Male
- Staphylococcus aureus/immunology*
- Teichoic Acids/immunology
- Transforming Growth Factor beta/immunology*
- Zebrafish/blood
- Zebrafish/immunology*
- Zebrafish Proteins/immunology*
- PubMed
- 20006406 Full text @ Immunobiology
Citation
Tong, Z., Li, L., Pawar, R., and Zhang, S. (2010) Vitellogenin is an acute phase protein with bacterial-binding and inhibiting activities. Immunobiology. 215(11):898-902.
Abstract
Previous studies have shown that vitellogenin (Vg) is an immune-relevant molecule, but its potential immunological role in vivo remains obscure. We demonstrated here that injection of lipopolysaccharide (LPS) and lipoteichoic acid (LTA) into male Danio rerio rapidly induced a significant up-regulation of Vg at both transcriptional and translational levels, and that serum Vg produced was able to bind to both Escherichia coli and Staphylococcus aureus and to inhibit their growth in a dose-dependent manner. All these data suggest that serum Vg in zebrafish D. rerio is an acute phase protein with bacterial-binding and inhibiting activities. It also bolsters the notion that factors normally involved in control of female reproduction are linked with immunity in organisms that rely on Vg for oocyte development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping