PUBLICATION
Tribbles: novel regulators of cell function; evolutionary aspects
- Authors
- Hegedus, Z., Czibula, A., and Kiss-Toth, E.
- ID
- ZDB-PUB-091204-8
- Date
- 2006
- Source
- Cellular and molecular life sciences : CMLS 63(14): 1632-1641 (Review)
- Registered Authors
- Keywords
- Signal transduction, tribbles, MAPK, Akt, ATF4, regulation of signalling, scaffolds
- MeSH Terms
-
- Protein Kinases/physiology
- Protein Tyrosine Phosphatases/physiology
- Protein Structure, Tertiary
- Animals
- Consensus Sequence
- Sequence Alignment
- Embryonic Development/genetics
- Embryonic Development/physiology
- Cell Cycle Proteins/chemistry
- Cell Cycle Proteins/genetics
- Cell Cycle Proteins/physiology*
- Molecular Sequence Data
- Morphogenesis/genetics
- Morphogenesis/physiology*
- Xenopus/physiology
- Humans
- Drosophila Proteins/chemistry
- Drosophila Proteins/deficiency
- Drosophila Proteins/genetics
- Drosophila Proteins/physiology
- Calcium-Calmodulin-Dependent Protein Kinases
- Xenopus Proteins/physiology
- Protein Serine-Threonine Kinases/chemistry
- Protein Serine-Threonine Kinases/deficiency
- Protein Serine-Threonine Kinases/genetics
- Protein Serine-Threonine Kinases/physiology*
- Expressed Sequence Tags
- Drosophila melanogaster/embryology
- Drosophila melanogaster/genetics
- Drosophila melanogaster/physiology
- Neoplasms/physiopathology
- Vertebrates/genetics
- Vertebrates/physiology
- Biological Evolution
- Amino Acid Sequence
- Gene Expression Regulation/genetics
- Gene Expression Regulation/physiology
- Intracellular Signaling Peptides and Proteins/chemistry
- Intracellular Signaling Peptides and Proteins/genetics
- Intracellular Signaling Peptides and Proteins/physiology*
- Repressor Proteins/chemistry
- Repressor Proteins/genetics
- Repressor Proteins/physiology*
- Evolution, Molecular*
- Starvation/physiopathology
- Autoimmune Diseases/physiopathology
- Sequence Homology, Amino Acid
- Species Specificity
- Cell Lineage
- Signal Transduction/genetics
- Signal Transduction/physiology*
- Invertebrates/genetics
- Invertebrates/physiology
- PubMed
- 16715410 Full text @ Cell. Mol. Life Sci.
Citation
Hegedus, Z., Czibula, A., and Kiss-Toth, E. (2006) Tribbles: novel regulators of cell function; evolutionary aspects. Cellular and molecular life sciences : CMLS. 63(14):1632-1641.
Abstract
Identification of rate-limiting steps or components of intracellular second messenger systems holds promise to effectively interfere with these pathways under pathological conditions. The emerging literature on a recently identified family of signalling regulator proteins, called tribbles gives interesting clues for how these proteins seem to link several 'independent' signal processing systems together. Via their unique way of action, tribbles co-ordinate the activation and suppression of the various interacting signalling pathways and therefore appear to be key in determining cell fate while responding to environmental challenges. This review summarises our current understanding of tribbles function and also provides an evolutionary perspective on the various tribbles genes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping