PUBLICATION
Tribbles: novel regulators of cell function; evolutionary aspects
- Authors
- Hegedus, Z., Czibula, A., and Kiss-Toth, E.
- ID
- ZDB-PUB-091204-8
- Date
- 2006
- Source
- Cellular and molecular life sciences : CMLS 63(14): 1632-1641 (Review)
- Registered Authors
- Keywords
- Signal transduction, tribbles, MAPK, Akt, ATF4, regulation of signalling, scaffolds
- MeSH Terms
-
- Humans
- Sequence Homology, Amino Acid
- Vertebrates/genetics
- Vertebrates/physiology
- Drosophila Proteins/chemistry
- Drosophila Proteins/deficiency
- Drosophila Proteins/genetics
- Drosophila Proteins/physiology
- Morphogenesis/genetics
- Morphogenesis/physiology*
- Signal Transduction/genetics
- Signal Transduction/physiology*
- Protein Serine-Threonine Kinases/chemistry
- Protein Serine-Threonine Kinases/deficiency
- Protein Serine-Threonine Kinases/genetics
- Protein Serine-Threonine Kinases/physiology*
- Embryonic Development/genetics
- Embryonic Development/physiology
- Consensus Sequence
- Invertebrates/genetics
- Invertebrates/physiology
- Species Specificity
- Amino Acid Sequence
- Calcium-Calmodulin-Dependent Protein Kinases
- Drosophila melanogaster/embryology
- Drosophila melanogaster/genetics
- Drosophila melanogaster/physiology
- Evolution, Molecular*
- Expressed Sequence Tags
- Sequence Alignment
- Starvation/physiopathology
- Protein Structure, Tertiary
- Protein Tyrosine Phosphatases/physiology
- Animals
- Xenopus Proteins/physiology
- Intracellular Signaling Peptides and Proteins/chemistry
- Intracellular Signaling Peptides and Proteins/genetics
- Intracellular Signaling Peptides and Proteins/physiology*
- Molecular Sequence Data
- Cell Lineage
- Autoimmune Diseases/physiopathology
- Cell Cycle Proteins/chemistry
- Cell Cycle Proteins/genetics
- Cell Cycle Proteins/physiology*
- Gene Expression Regulation/genetics
- Gene Expression Regulation/physiology
- Neoplasms/physiopathology
- Protein Kinases/physiology
- Repressor Proteins/chemistry
- Repressor Proteins/genetics
- Repressor Proteins/physiology*
- Xenopus/physiology
- Biological Evolution
- PubMed
- 16715410 Full text @ Cell. Mol. Life Sci.
Citation
Hegedus, Z., Czibula, A., and Kiss-Toth, E. (2006) Tribbles: novel regulators of cell function; evolutionary aspects. Cellular and molecular life sciences : CMLS. 63(14):1632-1641.
Abstract
Identification of rate-limiting steps or components of intracellular second messenger systems holds promise to effectively interfere with these pathways under pathological conditions. The emerging literature on a recently identified family of signalling regulator proteins, called tribbles gives interesting clues for how these proteins seem to link several 'independent' signal processing systems together. Via their unique way of action, tribbles co-ordinate the activation and suppression of the various interacting signalling pathways and therefore appear to be key in determining cell fate while responding to environmental challenges. This review summarises our current understanding of tribbles function and also provides an evolutionary perspective on the various tribbles genes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping