PUBLICATION
Tribbles: a family of kinase-like proteins with potent signalling regulatory function
- Authors
- Hegedus, Z., Czibula, A., and Kiss-Toth, E.
- ID
- ZDB-PUB-091204-7
- Date
- 2007
- Source
- Cellular Signalling 19(2): 238-250 (Review)
- Registered Authors
- Keywords
- Tribbles, Tribbles proteins
- MeSH Terms
-
- Nuclear Proteins/genetics
- Nuclear Proteins/metabolism*
- Signal Transduction
- Amino Acid Sequence
- Drosophila Proteins/genetics
- Drosophila Proteins/metabolism*
- Xenopus Proteins/metabolism*
- Models, Biological
- Humans
- Protein Structure, Tertiary
- Animals
- Conserved Sequence
- Protein Serine-Threonine Kinases/genetics
- Protein Serine-Threonine Kinases/metabolism*
- Evolution, Molecular
- Molecular Sequence Data
- Protein Kinases/metabolism*
- Cell Cycle Proteins/genetics
- Cell Cycle Proteins/metabolism*
- Phosphotransferases/genetics*
- Sequence Homology, Amino Acid
- Amino Acid Motifs
- Apoptosis Regulatory Proteins/genetics
- Apoptosis Regulatory Proteins/metabolism*
- PubMed
- 16963228 Full text @ Cell. Signal.
Citation
Hegedus, Z., Czibula, A., and Kiss-Toth, E. (2007) Tribbles: a family of kinase-like proteins with potent signalling regulatory function. Cellular Signalling. 19(2):238-250.
Abstract
The recent identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate activation of a number of intracellular signalling pathways with roles extending from mitosis and cell activation to apoptosis and modulation of gene expression. The current review summarises our current understanding of interactions between tribbles and various other proteins. Since our understanding on the molecular basis of tribbles function is far from complete, we also describe a bioinformatic analysis of various segments of tribbles proteins, which has revealed a number of highly conserved peptide motifs with potentially important functional roles.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping