PUBLICATION
A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family
- Authors
- Miwa, H., Miyake, A., Kouta, Y., Shimada, A., Yamashita, Y., Nakayama, Y., Yamauchi, H., Konishi, M., and Itoh, N.
- ID
- ZDB-PUB-091101-10
- Date
- 2009
- Source
- FEBS letters 583(22): 3643-3648 (Journal)
- Registered Authors
- Itoh, Nobuyuki, Konishi, Morichika, Miyake, Ayumi, Nakayama, Yoshiaki
- Keywords
- BMP, Antagonist, Chordin, Brain, Development, Gene expression
- MeSH Terms
-
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Astrocytes/cytology
- Astrocytes/metabolism
- Bone Morphogenetic Proteins/antagonists & inhibitors
- Bone Morphogenetic Proteins/metabolism*
- COS Cells
- Cell Differentiation/genetics
- Cells, Cultured
- Chlorocebus aethiops
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Glycoproteins/genetics*
- Glycoproteins/metabolism
- Glycoproteins/pharmacology
- Humans
- In Situ Hybridization
- Intercellular Signaling Peptides and Proteins/genetics*
- Intercellular Signaling Peptides and Proteins/metabolism
- Intercellular Signaling Peptides and Proteins/pharmacology
- Mice
- Molecular Sequence Data
- Nerve Tissue Proteins/genetics*
- Neurons/cytology
- Neurons/metabolism*
- Recombinant Proteins/metabolism
- Recombinant Proteins/pharmacology
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Homology, Amino Acid
- Signal Transduction/drug effects
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism
- PubMed
- 19852960 Full text @ FEBS Lett.
Citation
Miwa, H., Miyake, A., Kouta, Y., Shimada, A., Yamashita, Y., Nakayama, Y., Yamauchi, H., Konishi, M., and Itoh, N. (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS letters. 583(22):3643-3648.
Abstract
We identified a gene encoding a novel secreted protein in mice, humans, and zebrafish. As the protein of 222 amino acids is similar to Brorin, a secreted BMP antagonist, which is a member of the Chordin family, we named it Brorin-like. Recombinant Brorin-like protein weakly but significantly inhibited the activity of BMP in mouse preosteoblastic cells and promoted neurogenesis in mouse neural precursor cells. Brorin-like was predominantly expressed in the adult brain and embryonic neural tissues. The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development. Brorin-like potentially plays roles in neural development and functions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping