PUBLICATION

The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma formation

Authors
Powers, J., Zhao, Y., Lin, S., and McCabe, E.R.
ID
ZDB-PUB-091023-41
Date
2009
Source
Development genes and evolution   219(8): 419-425 (Journal)
Registered Authors
Lin, Shuo, Zhao, Yan
Keywords
dax1, Tooth, Ameloblasts, Ameloblastoma
MeSH Terms
  • Odontogenesis*
  • Homeodomain Proteins
  • Humans
  • Animals
  • Tooth/embryology
  • DAX-1 Orphan Nuclear Receptor/genetics
  • DAX-1 Orphan Nuclear Receptor/metabolism*
  • Embryo, Nonmammalian/metabolism
  • Ameloblastoma/genetics
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Zebrafish Proteins/metabolism*
  • Gene Expression Regulation, Developmental
(all 14)
PubMed
19826837 Full text @ Dev. Genes Evol.
Abstract
Zebrafish teeth develop on pharyngeal jaws in the 5th branchial arch, but early tooth development is remarkably similar to mammals (Borday-Birraux et al., Evol Dev 8:130, 2006). Recently, eve1 has been shown to be associated with the primary tooth (4V(1)) and early ameloblast development, the enamel organ precursor (Laurenti et al., Dev Dyn 230:727, 2004). dax1 is initially expressed in the 5th branchial arch in zebrafish at approximately 26 h postfertilization (hpf) and colocalizes with eve1 expression at ~48 hpf. Embryos injected with dax1 morpholino show downregulation of eve1 expression. Based on the zebrafish observations, we demonstrated novel DAX1 expression in normal human dental, benign ameloblastoma, and malignant ameloblastoma tissues. The association of NR0B1 and its protein product DAX1 with primary tooth development and ameloblastoma tumorigenesis is an association not previously described.
Genes / Markers
Figures
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Expression
Phenotype
No data available
Mutations / Transgenics
No data available
Human Disease / Model
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Sequence Targeting Reagents
Target Reagent Reagent Type
nr0b1MO1-nr0b1MRPHLNO
nr0b1MO2-nr0b1MRPHLNO
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Fish
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Antibodies
No data available
Orthology
No data available
Engineered Foreign Genes
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Mapping
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