PUBLICATION
Prdm1a is necessary for posterior pharyngeal arch development in zebrafish
- Authors
- Birkholz, D.A., Killian, E.C., George, K.M., and Artinger, K.B.
- ID
- ZDB-PUB-090929-9
- Date
- 2009
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 238(10): 2575-2587 (Journal)
- Registered Authors
- Artinger, Kristin Bruk
- Keywords
- prdm1a, neural crest, craniofacial development, zebrafish, pharyngeal arches, endodermal pouches, Fgf signaling, retinoic acid signaling
- MeSH Terms
-
- Tretinoin/metabolism
- Embryo, Nonmammalian*/anatomy & histology
- Embryo, Nonmammalian*/metabolism
- Gene Expression Regulation, Developmental
- Facial Bones/abnormalities
- PubMed
- 19777590 Full text @ Dev. Dyn.
Abstract
Multiple tissue interactions and signaling within the pharyngeal arches are required for development of the craniofacial skeleton. Here, we focus on the role of the transcription factor prdm1a in the differentiation of the posterior skeleton. prdm1a is expressed in the presumptive pharyngeal arch region and later in an endodermal pouch, the otic vesicle, and pharyngeal teeth. prdm1a mutants display a reduction in pharyngeal arch markers, a loss of posterior ceratobranchial cartilages, and a reduction in most neural crest-derived dermal bones. This is likely caused by a decrease in the number of proliferating cells but not an increase in cell death. Finally, a reduction in two key developmental signaling pathways, Fgf and retinoic acid, alters prdm1a expression, suggesting that prdm1a expression is mediated by these signaling pathways to pattern the posterior craniofacial skeleton. Together, these results indicate an essential role for prdm1a in the development of the zebrafish craniofacial skeleton.
Genes / Markers
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Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
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