PUBLICATION
Cardiosulfa, a Small Molecule that Induces Abnormal Heart Development in Zebrafish, and Its Biological Implications
- Authors
- Ko, S.K., Jin, H.J., Jung, D.W., Tian, X., and Shin, I.
- ID
- ZDB-PUB-090921-19
- Date
- 2009
- Source
- Angewandte Chemie (International ed. in English) 48(42): 7809-7812 (Journal)
- Registered Authors
- Keywords
- chemical genetics, combinatorial chemistry, screening, sulfonamides, zebrafish
- MeSH Terms
-
- Animals
- Heart Defects, Congenital/chemically induced*
- Zebrafish/embryology
- Heart/drug effects*
- Heart/embryology
- Carbazoles/chemistry
- Carbazoles/pharmacology*
- Sulfonamides/chemistry
- Sulfonamides/pharmacology*
- PubMed
- 19757464 Full text @ Angew. Chem. Int. Ed. Engl.
Citation
Ko, S.K., Jin, H.J., Jung, D.W., Tian, X., and Shin, I. (2009) Cardiosulfa, a Small Molecule that Induces Abnormal Heart Development in Zebrafish, and Its Biological Implications. Angewandte Chemie (International ed. in English). 48(42):7809-7812.
Abstract
A change of heart: Cardiosulfa, a small molecule that induces heart deformation during zebrafish development, has been identified by using a forward chemical-genetic approach. Zebrafish embryos exposed to cardiosulfa have a narrow and elongated heart within an enlarged pericardial sac (see picture; heart marked with green fluorescent protein).
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping