PUBLICATION

Cardiosulfa, a Small Molecule that Induces Abnormal Heart Development in Zebrafish, and Its Biological Implications

Authors
Ko, S.K., Jin, H.J., Jung, D.W., Tian, X., and Shin, I.
ID
ZDB-PUB-090921-19
Date
2009
Source
Angewandte Chemie (International ed. in English)   48(42): 7809-7812 (Journal)
Registered Authors
Keywords
chemical genetics, combinatorial chemistry, screening, sulfonamides, zebrafish
MeSH Terms
  • Heart/drug effects*
  • Heart/embryology
  • Animals
  • Carbazoles/chemistry
  • Carbazoles/pharmacology*
  • Sulfonamides/chemistry
  • Sulfonamides/pharmacology*
  • Heart Defects, Congenital/chemically induced*
  • Zebrafish/embryology
(all 9)
PubMed
19757464 Full text @ Angew. Chem. Int. Ed. Engl.
Abstract
A change of heart: Cardiosulfa, a small molecule that induces heart deformation during zebrafish development, has been identified by using a forward chemical-genetic approach. Zebrafish embryos exposed to cardiosulfa have a narrow and elongated heart within an enlarged pericardial sac (see picture; heart marked with green fluorescent protein).
Genes / Markers
Figures
No images available
Expression
Phenotype
No data available
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Ko, S.K., Jin, H.J., Jung, D.W., Tian, X., and Shin, I. (2009) Cardiosulfa, a Small Molecule that Induces Abnormal Heart Development in Zebrafish, and Its Biological Implications. Angewandte Chemie (International ed. in English). 48(42):7809-7812.