PUBLICATION
Development of the dopamine systems in zebrafish
- Authors
- Schweitzer, J., and Driever, W.
- ID
- ZDB-PUB-090914-31
- Date
- 2009
- Source
- Advances in experimental medicine and biology 651: 1-14 (Chapter)
- Registered Authors
- Driever, Wolfgang, Schweitzer, Jörn
- Keywords
- none
- MeSH Terms
-
- Animals
- Biological Evolution
- Brain/cytology
- Brain/embryology*
- Brain/metabolism*
- Dopamine/metabolism*
- Gene Expression Regulation, Developmental/physiology
- Models, Animal
- Neural Pathways/cytology
- Neural Pathways/embryology
- Neural Pathways/metabolism
- Neurogenesis/physiology
- Neurons/cytology
- Neurons/metabolism*
- Tyrosine 3-Monooxygenase/analysis
- Tyrosine 3-Monooxygenase/metabolism
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism*
- PubMed
- 19731546 Full text @ Adv. Exp. Med. Biol.
Citation
Schweitzer, J., and Driever, W. (2009) Development of the dopamine systems in zebrafish. Advances in experimental medicine and biology. 651:1-14.
Abstract
Dopaminergic neurons develop in several distinct regions of the vertebrate brain and project locally or send long axonal projections to distant parts of the CNS to modulate the activity of a variety of circuits, controlling aspects of physiology, behavior and movement. The molecular control of dopaminergic differentiation and the evolution of the various dopaminergic systems are not well understood, as research has mostly focused on ascending mammalian dopaminergic systems of the substantia nigra and ventral tegmental area. Zebrafish have evolved as an excellent genetic and experimental embryological model to study specification and axonal projectivity of dopaminergic neurons. The large evolutionary distance between fish and mammals provides the opportunity to identify conserved core regulatory mechanisms that control differentiation and projection behavior of the various dopaminergic groups in vertebrates. Here, we present an overview of the formation of dopaminergic groups and their projections in zebrafish. We will further review the results from genetic analyses, which have revealed insights on signals as well as transcription factors contributing to dopaminergic differentiation. Together with recently established paradigms for behavioral analysis, dopaminergic systems are studied at all levels in zebrafish, from molecular and cellular to systems and behavioral.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping