ZFIN ID: ZDB-PUB-090914-2
Toxicity and Developmental Defects of Different Sizes and Shape Nickel Nanoparticles in Zebrafish
Ispas, C., Andreescu, D., Patel, A., Goia, D.V., Andreescu, S., and Wallace, K.N.
Date: 2009
Source: Environmental science & technology   43(16): 6349-6356 (Journal)
Registered Authors: Wallace, Kenneth
Keywords: IN-VIVO, SILVER NANOPARTICLES, PARTICLE SOLUBILITY, DANIO-RERIO, CYTOTOXICITY, NANOMATERIALS, CELLS, EMBRYOS
MeSH Terms:
  • Animals
  • Body Patterning/drug effects
  • Embryo, Nonmammalian/abnormalities*
  • Embryo, Nonmammalian/drug effects*
  • Gastrointestinal Tract/drug effects
  • Gastrointestinal Tract/metabolism
  • Hydrogen-Ion Concentration/drug effects
  • Jaw/drug effects
  • Jaw/embryology
  • Jaw Abnormalities/embryology
  • Nanoparticles/toxicity*
  • Nanoparticles/ultrastructure
  • Nickel/chemistry
  • Nickel/toxicity*
  • Particle Size*
  • Solubility
  • Toxicity Tests*
  • X-Ray Diffraction
  • Zebrafish/embryology*
PubMed: 19746736 Full text @ Env. Sci. Tech.
ABSTRACT
Metallic nanoparticles such as nickel are used in catalytic, sensing,and electronic applications, but health and environmental affects have not been fully investigated. While some metal nanoparticles result in toxicity, it is also important to determine whether nanoparticles of the same metal but of different size and shape changes toxicity. Three different size nickel nanoparticle (Ni NPs) of 30, 60, and 100 nm and larger particle Clusters of aggregated 60 nm entities with a dendritic structure were synthesized and exposed to zebrafish embryos assessing mortality and developmental detects. Ni NPs exposure was compared to Soluble nickel salts, All three 30, 60, and 100 nm Ni NPs are equal to or less toxic than soluble nickel while dendritic clusters were more toxic. With each Ni NP exposure, thinning of the intestinal epithelium first occurs around the LD10 continuing into the LD50. LD50 exposure also results in skeletal muscle fiber separation. Exposure to soluble nickel does not cause intestinal defects while skeletal muscle separation occurs at concentrations well over LD50. These results suggest that configuration of nanoparticles may affect toxicity more than size and defects from Ni NPs exposure occur by different biological mechanisms than soluble nickel.
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