PUBLICATION
Genomic regulatory blocks in vertebrates and implications in human disease
- Authors
- Navratilova, P., and Becker, T.S.
- ID
- ZDB-PUB-090706-4
- Date
- 2009
- Source
- Briefings in functional genomics & proteomics 8(4): 333-342 (Review)
- Registered Authors
- Becker, Thomas S., Navratilova, Pavla
- Keywords
- whole genome duplication, GWAS, bystander gene
- MeSH Terms
-
- Animals
- DNA, Intergenic/genetics
- Disease/genetics*
- Genome/genetics*
- Humans
- Regulatory Sequences, Nucleic Acid/genetics*
- Synteny/genetics
- Vertebrates/genetics*
- PubMed
- 19561171 Full text @ Brief. Funct. Genomic. Proteomic.
Citation
Navratilova, P., and Becker, T.S. (2009) Genomic regulatory blocks in vertebrates and implications in human disease. Briefings in functional genomics & proteomics. 8(4):333-342.
Abstract
Despite a recent explosion in the production of vertebrate genome sequence data and large-scale efforts to completely annotate the human genome, we still have scant knowledge of the principles that built vertebrate genomes in evolution, and of genome architecture and its functional significance. We review approaches using bioinformatics, zebrafish transgenesis, and recent findings in the molecular basis of gene regulation and tie these in with mechanisms for the maintenance of long-range conserved synteny across all vertebrate genomes. Specifically, we discuss the recently discovered genomic regulatory blocks which we argue are principal units of vertebrate genome evolution and serve as the foundations onto which evolutionary innovations are built through sequence evolution and insertion of new cis-regulatory elements. We subsequently discuss how these arrangements relate to common human heritable diseases and their significance in disease causality.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping