PUBLICATION

Transcriptome analysis of the zebrafish pineal gland

Authors
Toyama, R., Chen, X., Jhawar, N., Aamar, E., Epstein, J., Reany, N., Alon, S., Gothilf, Y., Klein, D.C., and Dawid, I.B.
ID
ZDB-PUB-090616-42
Date
2009
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   238(7): 1813-1826 (Journal)
Registered Authors
Aamar, Emil, Dawid, Igor B., Epstein, Jonathan, Gothilf, Yoav, Klein, David C., Toyama, Reiko
Keywords
pineal gland, epiphysis, zebrafish, circadian rhythm, microarray
Datasets
GEO:GSE13371
MeSH Terms
  • Gene Expression Profiling*
  • Gene Expression Regulation, Developmental
  • Eye Proteins/genetics
  • Eye Proteins/metabolism
  • Pineal Gland/growth & development
  • Pineal Gland/metabolism*
  • Zebrafish/genetics*
  • Zebrafish/growth & development
  • Zebrafish/metabolism
  • Photoperiod
  • Brain/metabolism
  • Animals
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • Zebrafish Proteins/physiology
  • Cluster Analysis
  • Circadian Rhythm/genetics
  • Oligonucleotide Array Sequence Analysis
(all 18)
PubMed
19504458 Full text @ Dev. Dyn.
Abstract
The zebrafish pineal gland (epiphysis) is a site of melatonin production, contains photoreceptor cells, and functions as a circadian clock pace maker. Here, we have used microarray technology to study the zebrafish pineal transcriptome. Analysis of gene expression at three larval and two adult stages revealed a highly dynamic transcriptional profile, revealing many genes that are highly expressed in the zebrafish pineal gland. Statistical analysis of the data based on Gene Ontology annotation indicates that many transcription factors are highly expressed during larval stages, whereas genes dedicated to phototransduction are preferentially expressed in the adult. Furthermore, several genes were identified that exhibit day/night differences in expression. Among the multiple candidate genes suggested by these data, we note the identification of a tissue-specific form of the unc119 gene with a possible role in pineal development.
Genes / Markers
Figures
Figure Gallery (2 images)
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Expression
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay Figure
WTstandard conditionsProtruding-mouthISH
WTstandard conditionsProtruding-mouthISH
WTstandard conditions20-25 somitesNot DetectedISH
1 - 3 of 3
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Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
y9TgTransgenic Insertion
    1 - 1 of 1
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    Human Disease / Model
    No data available
    Sequence Targeting Reagents
    No data available
    Fish
    Fish
    WT
    y9Tg
    1 - 2 of 2
    Show
    Antibodies
    No data available
    Orthology
    No data available
    Engineered Foreign Genes
    Marker Marker Type Name
    EGFPEFGEGFP
    1 - 1 of 1
    Show
    Mapping
    No data available
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    Citation
    Toyama, R., Chen, X., Jhawar, N., Aamar, E., Epstein, J., Reany, N., Alon, S., Gothilf, Y., Klein, D.C., and Dawid, I.B. (2009) Transcriptome analysis of the zebrafish pineal gland. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(7):1813-1826.