ZFIN ID: ZDB-PUB-090518-4
A Comprehensive Overview of the Vertebrate p24 Family: Identification of a Novel Tissue-Specifically Expressed Member
Strating, J.R., van Bakel, N.N., Leunissen, J.A., and Martens, G.J.
Date: 2009
Source: Mol. Biol. Evol.   26(8): 1707-1714 (Journal)
Registered Authors:
Keywords: Early secretory pathway, phylogeny, evolutionary tree, tissue distribution, p23 p25 p26 p27 tp24 gp25L, TMED
MeSH Terms:
  • Animals
  • Carrier Proteins/genetics*
  • Codon, Terminator
  • Female
  • Gene Expression Regulation
  • Humans
  • Membrane Proteins/genetics*
  • Mice
  • Phylogeny
  • Vertebrates/genetics*
PubMed: 19429673 Full text @ Mol. Biol. Evol.
The members of the p24 protein family have an important but unclear role in transport processes in the early secretory pathway. The p24 family consists of four subfamilies (alpha, beta, gamma and delta), whereby the exact composition of the family varies among species. Despite more than 15 years of p24 research, the vertebrate p24 family is still surprisingly ill characterised. Here we describe the human, mouse, Xenopus and zebrafish orthologues of ten p24 family members and a new member that we term p24gamma(5). Of these eleven p24 family members, nine are conserved throughout the vertebrate lineage, whereas two (p24gamma(4) and p24delta(2)) occur in some but not all vertebrates. We further show that all p24 proteins are widely expressed in mouse, except for p24alpha(1) and p24gamma(5) that display restricted expression patterns. Thus, we present for the first time a comprehensive overview of the phylogeny and expression of the vertebrate p24 protein family, including of a novel member.