PUBLICATION
Endocrine/Paracrine Control of Zebrafish Ovarian Development
- Authors
- Clelland, E., and Peng, C.
- ID
- ZDB-PUB-090505-9
- Date
- 2009
- Source
- Molecular and Cellular Endocrinology 312(1-2): 42-52 (Review)
- Registered Authors
- Peng, Chun
- Keywords
- none
- MeSH Terms
-
- Animals
- Endocrine System/growth & development
- Endocrine System/physiology*
- Female
- Gonadotropin-Releasing Hormone/metabolism
- Gonadotropin-Releasing Hormone/physiology
- Gonadotropins/metabolism
- Gonadotropins/physiology
- Oocytes/growth & development
- Ovarian Follicle/growth & development
- Ovary/embryology
- Ovary/growth & development*
- Ovary/metabolism
- Paracrine Communication/physiology*
- Vitellogenesis
- Zebrafish/embryology
- Zebrafish/growth & development*
- Zebrafish/metabolism
- PubMed
- 19406202 Full text @ Mol. Cell. Endocrinol.
Citation
Clelland, E., and Peng, C. (2009) Endocrine/Paracrine Control of Zebrafish Ovarian Development. Molecular and Cellular Endocrinology. 312(1-2):42-52.
Abstract
Ovarian differentiation and the processes of follicle development, oocyte maturation and ovulation are complex events, requiring the coordinated action of regulatory molecules. In zebrafish, ovarian development is initiated at 10 days after hatching and fish become sexually mature at 3 months. Adult zebrafish have asynchronous ovaries, which contain follicles of all stages of development. Eggs are spawned daily under proper environmental conditions in a population of zebrafish, with individual females spawning irregularly every 4-7 days in mixed sex conditions. Maximal embryo viability is achieved when sexually isolated females are bred in 10 day intervals [1]. Similar to other vertebrates, hormones from the hypothalamus-pituitary-gonadal axis play important roles in regulating follicle development. Follicle stimulating hormone (FSH) stimulates estradiol production, which in turn, promotes viteollogenesis. Luteinizing hormone (LH) stimulates the production of 17, 20beta-dihydroxy-4-pregnen-3-one (17,20betaP) or maturation inducing hormone (MIH) which acts through membrane progestin receptors to activate maturation promoting factor, leading to oocyte maturation. Recent studies in zebrafish have also provided novel insights into the functions of ovary-derived growth factors in follicle development and oocyte maturation. The present review summarizes the current knowledge on how endocrine and paracrine factors regulate ovarian development in zebrafish. Special emphasis is placed on how follicle development and oocyte maturation in adult females is regulated by gonadotropins, ovarian steroids and growth factors produced by the ovary.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping