ZFIN ID: ZDB-PUB-090324-4
Roles of planar cell polarity pathway genes for neural migration and differentiation
Wada, H., and Okamoto, H.
Date: 2009
Source: Development, Growth & Differentiation 51(3): 233-240 (Review)
Registered Authors: Okamoto, Hitoshi, Wada, Hironori
Keywords: axonal pathfinding, neural migration, non-canonical Wnt signaling, planar cell polarity, zebrafish
MeSH Terms:
  • Animals
  • Cell Differentiation/genetics
  • Cell Differentiation/physiology*
  • Cell Movement/genetics
  • Cell Movement/physiology*
  • Cell Polarity/genetics
  • Cell Polarity/physiology*
  • Drosophila
  • Mice
  • Neurons/cytology*
  • Neurons/metabolism*
  • Prosencephalon/anatomy & histology
  • Prosencephalon/cytology
  • Prosencephalon/metabolism
  • Signal Transduction
  • Spinal Cord/anatomy & histology
  • Spinal Cord/cytology
  • Spinal Cord/metabolism
  • Zebrafish
PubMed: 19298553 Full text @ Dev. Growth Differ.
Planar cell polarity (PCP) in epithelial cells is essential for the organization of tissues and their functions. The conserved non-canonical Wnt/PCP pathway regulates this process in both Drosophila and vertebrates. However, recent studies have revealed that a similar set of genes, which may not be related to PCP, regulates oriented cell movement during development. In the present review, recent findings on neural migration in zebrafish hindbrain and axonal guidance in mouse forebrain and spinal cord are discussed. Future analyses on defects in vertebrate PCP mutants will provide novel insights into the conserved and diverse roles of non-canonical Wnt/PCP pathway genes in vertebrate brain development.