PUBLICATION

Noncanonical Wnt Signaling in Tumor Progression and Metastasis

Authors
Jessen, J.R.
ID
ZDB-PUB-090320-1
Date
2009
Source
Zebrafish   6(1): 21-28 (Review)
Registered Authors
Jessen, Jason R.
Keywords
none
MeSH Terms
  • Animals
  • Cell Movement
  • Neoplasm Metastasis*
  • Neoplasms/metabolism*
  • Signal Transduction*
  • Wnt Proteins/metabolism*
  • Zebrafish/metabolism*
PubMed
19292672 Full text @ Zebrafish
Abstract
For almost 15 years, the concept that noncanonical (beta-catenin-independent) Wnt signaling pathways play key roles in embryonic development has grown steadily in the scientific literature. Significant progress has been made toward understanding how these pathways regulate morphogenetic processes as diverse as gastrulation cell movements and the formation of cilia. More recently, however, data have implicated components of noncanonical Wnt/Ca(2+) and Wnt/planar cell polarity signaling in directly promoting the invasiveness and malignant progression of diverse forms of human cancer. Here I review this emerging field of cancer research using data from developmental model systems to provide a framework for addressing future questions.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping