PUBLICATION
A Student Team in a University of Michigan Biomedical Engineering Design Course Constructs a Microfluidic Bioreactor for Studies of Zebrafish Development
- Authors
- Shen, Y.C., Li, D., Al-Shoaibi, A., Bersano-Begey, T., Chen, H., Ali, S., Flak, B., Perrin, C., Winslow, M., Shah, H., Ramamurthy, P., Schmedlen, R.H., Takayama, S., and Barald, K.F.
- ID
- ZDB-PUB-090319-15
- Date
- 2009
- Source
- Zebrafish 6(2): 201-213 (Journal)
- Registered Authors
- Barald, Kate, Shen, YuChi
- Keywords
- none
- MeSH Terms
-
- Animals
- Biomedical Engineering/education*
- Biomedical Engineering/methods
- Microfluidic Analytical Techniques*
- Universities
- Zebrafish/embryology*
- PubMed
- 19292670 Full text @ Zebrafish
Citation
Shen, Y.C., Li, D., Al-Shoaibi, A., Bersano-Begey, T., Chen, H., Ali, S., Flak, B., Perrin, C., Winslow, M., Shah, H., Ramamurthy, P., Schmedlen, R.H., Takayama, S., and Barald, K.F. (2009) A Student Team in a University of Michigan Biomedical Engineering Design Course Constructs a Microfluidic Bioreactor for Studies of Zebrafish Development. Zebrafish. 6(2):201-213.
Abstract
The zebrafish is a valuable model for teaching developmental, molecular, and cell biology; aquatic sciences; comparative anatomy; physiology; and genetics. Here we demonstrate that zebrafish provide an excellent model system to teach engineering principles. A seven-member undergraduate team in a biomedical engineering class designed, built, and tested a zebrafish microfluidic bioreactor applying microfluidics, an emerging engineering technology, to study zebrafish development. During the semester, students learned engineering and biology experimental design, chip microfabrication, mathematical modeling, zebrafish husbandry, principles of developmental biology, fluid dynamics, microscopy, and basic molecular biology theory and techniques. The team worked to maximize each person's contribution and presented weekly written and oral reports. Two postdoctoral fellows, a graduate student, and three faculty instructors coordinated and directed the team in an optimal blending of engineering, molecular, and developmental biology skill sets. The students presented two posters, including one at the Zebrafish meetings in Madison, Wisconsin (June 2008).
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping