PUBLICATION
Dusp-5 and Snrk-1 coordinately function during vascular development and disease
- Authors
- Pramanik, K., Chun, C.Z., Garnaas, M.K., Samant, G.V., Li, K., Horswill, M.A., North, P.E., and Ramchandran, R.
- ID
- ZDB-PUB-090311-3
- Date
- 2009
- Source
- Blood 113(5): 1184-1191 (Journal)
- Registered Authors
- Garnaas, Maija, Ramchandran, Ramani
- Keywords
- none
- MeSH Terms
-
- Animals
- Blood Vessels/embryology*
- Blood Vessels/pathology
- Dual-Specificity Phosphatases/biosynthesis*
- Dual-Specificity Phosphatases/genetics
- Gene Expression Regulation*/genetics
- Hemangioma/enzymology*
- Hemangioma/genetics
- Hemangioma/pathology
- Humans
- Mesoderm/blood supply*
- Mesoderm/embryology
- Mesoderm/pathology
- Mutation
- Neoplasm Proteins/biosynthesis*
- Neoplasm Proteins/genetics
- Protein Serine-Threonine Kinases/biosynthesis*
- Protein Serine-Threonine Kinases/genetics
- Signal Transduction/genetics
- Zebrafish/embryology*
- Zebrafish Proteins/biosynthesis*
- Zebrafish Proteins/genetics
- PubMed
- 18927432 Full text @ Blood
Citation
Pramanik, K., Chun, C.Z., Garnaas, M.K., Samant, G.V., Li, K., Horswill, M.A., North, P.E., and Ramchandran, R. (2009) Dusp-5 and Snrk-1 coordinately function during vascular development and disease. Blood. 113(5):1184-1191.
Abstract
Mitogen-activated protein kinases play an integral role in several cellular processes. To regulate mitogen-activated protein kinases, cells express members of a counteracting group of proteins called phosphatases. In this study, we have identified a specific role that one member of this family of phosphatases, dual-specific phosphatase-5 (Dusp-5) plays in vascular development in vivo. We have determined that dusp-5 is expressed in angioblasts and in established vasculature and that it counteracts the function of a serine threonine kinase, Snrk-1, which also plays a functional role in angioblast development. Together, Dusp-5 and Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1. Importantly, mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1-Dusp-5 signaling pathway in human disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping