PUBLICATION

The Emerging Role of Wnt/PCP Signaling in Organ Formation

Authors
Dale, R.M., Sisson, B.E., and Topczewski, J.
ID
ZDB-PUB-090309-2
Date
2009
Source
Zebrafish   6(1): 9-14 (Review)
Registered Authors
Dale, Rodney M., Sisson, Barbara E., Topczewski, Jacek
Keywords
none
MeSH Terms
  • Animals
  • Organogenesis*
  • Signal Transduction*
  • Wnt Proteins/metabolism*
  • Zebrafish/embryology*
  • Zebrafish/metabolism
PubMed
19250029 Full text @ Zebrafish
Abstract
Over the last two decades zebrafish has been an excellent model organism to study vertebrate development. Mutant analysis combined with gene knockdown and other manipulations revealed an essential role of Wnt signaling, independent of beta-catenin, during development. Especially well characterized is the function of Wnt/planar cell polarity (PCP) signaling in the regulation of gastrulation movements and neurulation, described in other reviews within this special issue. Here, we set out to highlight some of the new and exciting research that is being carried out in zebrafish to elucidate the role that Wnt/PCP signaling plays in the formation of specific organs, including the lateral line, craniofacial development, and regeneration. We also summarized the emerging connection of the Wnt/PCP pathway with primary cilia function, an essential organelle in several organ activities.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes