PUBLICATION
Feathers and Fins: Non-mammalian models for hair cell regeneration
- Authors
- Brignull, H.R., Raible, D.W., and Stone, J.S.
- ID
- ZDB-PUB-090302-30
- Date
- 2009
- Source
- Brain research 1277: 12-23 (Review)
- Registered Authors
- Raible, David
- Keywords
- hair cell regeneration, chick, zebrafish, ear, lateral line
- MeSH Terms
-
- Animals
- Cell Differentiation/physiology
- Cell Proliferation
- Chickens/anatomy & histology
- Hair Cells, Auditory/cytology*
- Hair Cells, Auditory/physiology*
- Mice
- Models, Animal*
- Regeneration/physiology*
- Zebrafish/anatomy & histology
- PubMed
- 19245801 Full text @ Brain Res.
Citation
Brignull, H.R., Raible, D.W., and Stone, J.S. (2009) Feathers and Fins: Non-mammalian models for hair cell regeneration. Brain research. 1277:12-23.
Abstract
Death of mechanosensory cells in the inner ear results in two profound disabilities: hearing loss and balance disorders. Although mammals lack the capacity to regenerate hair cells, recent studies in mice and other rodents have offered valuable insight into strategies for stimulating hair cell regeneration in mammals. Investigations of model organisms that retain the ability to form new hair cells after embryogenesis, such as fish and chicks, are equally important and have provided clues as to the cellular and molecular mechanisms that may block hair cell regeneration in mammals. Here, we summarize studies on hair cell regeneration in the chicken and the zebrafish, discuss specific advantages of each model, and propose future directions for the use of non-mammalian models in understanding hair cell regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping