PUBLICATION

Other model organisms for sarcomeric muscle diseases

Authors
Sparrow, J., Hughes, S.M., and Segalat, L.
ID
ZDB-PUB-090209-2
Date
2008
Source
Advances in experimental medicine and biology   642: 192-206 (Review)
Registered Authors
Hughes, Simon M.
Keywords
none
MeSH Terms
  • Animals
  • Cell Differentiation
  • Disease Models, Animal
  • Genome/genetics
  • Humans
  • Muscular Diseases/genetics
  • Muscular Diseases/metabolism*
  • Muscular Diseases/pathology
  • Sarcomeres/metabolism*
PubMed
19181102 Full text @ Adv. Exp. Med. Biol.
Abstract
Model organisms are vital to our understanding of human muscle biology and disease. The potential of the nematode Caenorhabditis elegans, the fruitfly, Drosophila melanogaster and the zebrafish, Danio rerio, as model genetic organisms for the study of human muscle disease is discussed by examining their muscle biology, muscle genetics and development. The powerful genetic tools available with each organism are outlined. It is concluded that these organisms have already demonstrated potential in facilitating the study of muscle disease and in screening for therapeutic agents.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes