PUBLICATION
The role of the ETS factor erg in zebrafish vasculogenesis
- Authors
- Ellett, F., Kile, B.T., and Lieschke, G.J.
- ID
- ZDB-PUB-081203-7
- Date
- 2009
- Source
- Mechanisms of Development 126(3-4): 220-229 (Journal)
- Registered Authors
- Ellett, Felix, Lieschke, Graham J.
- Keywords
- none
- MeSH Terms
-
- Mesoderm/cytology
- Mesoderm/metabolism
- Zebrafish Proteins/chemistry
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- Gene Expression Regulation, Developmental
- Zebrafish/embryology*
- Zebrafish/genetics
- Molecular Sequence Data
- Ether-A-Go-Go Potassium Channels/chemistry
- Ether-A-Go-Go Potassium Channels/genetics
- Ether-A-Go-Go Potassium Channels/metabolism*
- Sequence Analysis, Protein
- Amino Acid Sequence
- Body Patterning
- Cell Proliferation
- Animals
- Phylogeny
- Conserved Sequence
- Blood Vessels/cytology
- Blood Vessels/embryology*
- Blood Vessels/metabolism
- Morphogenesis*
- Models, Biological
- Proto-Oncogene Proteins c-ets/chemistry
- Proto-Oncogene Proteins c-ets/genetics
- Proto-Oncogene Proteins c-ets/metabolism*
- PubMed
- 19027849 Full text @ Mech. Dev.
Citation
Ellett, F., Kile, B.T., and Lieschke, G.J. (2009) The role of the ETS factor erg in zebrafish vasculogenesis. Mechanisms of Development. 126(3-4):220-229.
Abstract
Erg, a member of the ETS family of transcription factors, has been implicated by previous studies in endothelial and haematopoietic development. Deregulation of the human ERG locus is associated with acute myeloid leukaemia, prostate cancer and Ewing's sarcoma. To better understand the role of Erg during early development, we utilised the zebrafish as a model amenable to descriptive and functional studies in vivo. Zebrafish have a single erg gene that is expressed in mesoderm and its vascular derivatives during angioblast migration, vasculogenesis and early angiogenesis. Mutant and morphant expression analyses placed erg in a genetic pathway downstream of cloche, tal1/scl and etsrp during early angioblast migration. Furthermore, a combination of gain-of-function and loss-of-function studies suggested a redundant yet specific role for erg in both angioblast specification/proliferation and early angiogenesis, and a synergistic interaction with the critical ETS factor etsrp.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping