PUBLICATION

The role of the ETS factor erg in zebrafish vasculogenesis

Authors
Ellett, F., Kile, B.T., and Lieschke, G.J.
ID
ZDB-PUB-081203-7
Date
2009
Source
Mechanisms of Development   126(3-4): 220-229 (Journal)
Registered Authors
Ellett, Felix, Lieschke, Graham J.
Keywords
none
MeSH Terms
  • Phylogeny
  • Cell Proliferation
  • Conserved Sequence
  • Models, Biological
  • Body Patterning
  • Ether-A-Go-Go Potassium Channels/chemistry
  • Ether-A-Go-Go Potassium Channels/genetics
  • Ether-A-Go-Go Potassium Channels/metabolism*
  • Gene Expression Regulation, Developmental
  • Blood Vessels/cytology
  • Blood Vessels/embryology*
  • Blood Vessels/metabolism
  • Sequence Analysis, Protein
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Morphogenesis*
  • Mesoderm/cytology
  • Mesoderm/metabolism
  • Zebrafish Proteins/chemistry
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • Molecular Sequence Data
  • Animals
  • Proto-Oncogene Proteins c-ets/chemistry
  • Proto-Oncogene Proteins c-ets/genetics
  • Proto-Oncogene Proteins c-ets/metabolism*
  • Amino Acid Sequence
(all 27)
PubMed
19027849 Full text @ Mech. Dev.
Abstract
Erg, a member of the ETS family of transcription factors, has been implicated by previous studies in endothelial and haematopoietic development. Deregulation of the human ERG locus is associated with acute myeloid leukaemia, prostate cancer and Ewing's sarcoma. To better understand the role of Erg during early development, we utilised the zebrafish as a model amenable to descriptive and functional studies in vivo. Zebrafish have a single erg gene that is expressed in mesoderm and its vascular derivatives during angioblast migration, vasculogenesis and early angiogenesis. Mutant and morphant expression analyses placed erg in a genetic pathway downstream of cloche, tal1/scl and etsrp during early angioblast migration. Furthermore, a combination of gain-of-function and loss-of-function studies suggested a redundant yet specific role for erg in both angioblast specification/proliferation and early angiogenesis, and a synergistic interaction with the critical ETS factor etsrp.
Genes / Markers
Figures
Figure Gallery (6 images)
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Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
m39
    Deficiency
    y1TgTransgenic Insertion
      1 - 2 of 2
      Show
      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      Target Reagent Reagent Type
      ergMO1-ergMRPHLNO
      etsrpMO1-etsrpMRPHLNO
      tal1MO1-tal1MRPHLNO
      tal1MO2-tal1MRPHLNO
      1 - 4 of 4
      Show
      Fish
      Antibodies
      No data available
      Orthology
      No data available
      Engineered Foreign Genes
      Marker Marker Type Name
      EGFPEFGEGFP
      1 - 1 of 1
      Show
      Mapping
      No data available