PUBLICATION
Identification and expression of voltage-gated calcium channel beta subunits in Zebrafish
- Authors
- Zhou, W., Horstick, E.J., Hirata, H., and Kuwada, J.Y.
- ID
- ZDB-PUB-081203-16
- Date
- 2008
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 237(12): 3842-3852 (Journal)
- Registered Authors
- Hirata, Hiromi, Kuwada, John, Zhou, Weibin
- Keywords
- zebrafish, voltage-gated calcium channel, CACNB, spinal cord, nervous system, Rohon-Beard neuron, trigeminal ganglion, lateral line ganglion, heart, retina, VGCC
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Calcium Channels/chemistry
- Calcium Channels/classification
- Calcium Channels/genetics
- Calcium Channels/metabolism*
- Gene Expression Regulation, Developmental
- Humans
- Ion Channel Gating*
- Molecular Sequence Data
- Phylogeny
- Protein Subunits/chemistry
- Protein Subunits/classification
- Protein Subunits/genetics
- Protein Subunits/metabolism
- Retina/embryology
- Retina/metabolism
- Sequence Alignment
- Sequence Homology
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism*
- PubMed
- 19035348 Full text @ Dev. Dyn.
Citation
Zhou, W., Horstick, E.J., Hirata, H., and Kuwada, J.Y. (2008) Identification and expression of voltage-gated calcium channel beta subunits in Zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3842-3852.
Abstract
Voltage-gated calcium channels (VGCC) play important roles in electrically excitable cells and embryonic development. The VGCC beta subunits are essential for membrane localization of the channel and exert modulatory effects on channel functions. In mammals, the VGCC beta subunit gene family contains four members. In zebrafish, there appear to be seven VGCC beta subunits including the previously identified beta1 subunit. cDNAs for six additional VGCC beta subunit homologs were identified in zebrafish, their chromosomal locations determined and their expression patterns characterized during embryonic development. These six genes are primarily expressed in the nervous system with cacnb4a also expressed in the developing heart. Sequence homology, genomic synteny and expression patterns suggest that there are three pairs of duplicate genes for beta2, beta3, and beta4 in zebrafish with distinct expression patterns during embryonic development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping