PUBLICATION
Potential role of bone morphogenetic protein-15 in zebrafish follicle development and oocyte maturation
- Authors
- Peng, C., Clelland, E., and Tan, Q.
- ID
- ZDB-PUB-081029-20
- Date
- 2009
- Source
- Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 153(1): 83-87 (Review)
- Registered Authors
- Peng, Chun
- Keywords
- none
- MeSH Terms
-
- Animals
- Bone Morphogenetic Protein 15/chemistry
- Bone Morphogenetic Protein 15/metabolism*
- Female
- Oocytes/growth & development*
- Oogenesis*
- Ovarian Follicle/growth & development*
- Ovarian Follicle/metabolism*
- Zebrafish/growth & development*
- Zebrafish/metabolism*
- PubMed
- 18951993 Full text @ Comp. Biochem. Physiol. A Mol. Integr. Physiol.
Citation
Peng, C., Clelland, E., and Tan, Q. (2009) Potential role of bone morphogenetic protein-15 in zebrafish follicle development and oocyte maturation. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 153(1):83-87.
Abstract
Bone morphogenetic protein (BMP)-15 is a member of the transforming growth factor beta (TGF-beta) superfamily and is closely related to growth and differentiation factor (GDF)-9, both structurally and functionally. In mammals, BMP-15 is predominantly produced by oocytes and exerts important regulatory functions within the ovary, such as promoting early folliculogenesis, preventing premature luteinization and enhancing cumulus cell expansion. The role of BMP-15 in mammalian ovary differs between monoovulatory and polyovulatory species. Recent studies in zebrafish have provided initial evidence that BMP-15 is also an important regulator of ovarian functions. BMP-15 is produced by the zebrafish ovary throughout follicle development and maturation. In vitro studies using zebrafish follicles have revealed that incubation with recombinant human BMP-15 or over-expression of BMP-15 in oocytes results in an inhibition of gonadotropin- and maturation inducing hormone (MIH)-induced oocyte maturation. Conversely, immnunoneutralization with BMP-15 antiserum or silencing of BMP-15 expression using morpholino antisense oligonueclotides enhances oocyte maturation. A key step in BMP-15 action is the sensitivity of follicles to MIH. In vivo injection of BMP-15 antiserum causes a significant decrease in maturation-incompetent (insensitive to MIH) small early growth phase follicles and a concomitant increase in mature follicles. These findings support a role in BMP-15 in preventing precocious oocyte maturation in zebrafish. We propose that the suppression of premature oocyte maturation by BMP-15 may be important to maintain oocyte quality and subsequent ovulation and fertilization.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping