PUBLICATION

Genotoxic effect of 2,4,6-trichlorophenol on p53 gene in zebrafish liver

Authors
Yin, D., Zhu, H., Hu, P., and Zhao, Q.
ID
ZDB-PUB-081028-8
Date
2009
Source
Environmental toxicology and chemistry   28(3): 603-608 (Journal)
Registered Authors
Zhao, Qingshun
Keywords
2,4,6-Trichlorophenol, Zebrafish, p53 Gene, Point mutation, Genotoxicity
MeSH Terms
  • Animals
  • Chlorophenols/toxicity*
  • Liver/drug effects*
  • Mutagens
  • Point Mutation/drug effects
  • Tumor Suppressor Protein p53/genetics*
  • Zebrafish
PubMed
18939895 Full text @ Environ. Toxicol. Chem.
CTD
18939895
Abstract
The trichlorophenol (2,4,6-Trichlorophenol, TCP), a probable human carcinogen, is widely present in the environment. Employing denaturing high-performance liquid chromatography and DNA sequencing analyses, we demonstrated that 10 d exposure of zebrafish to TCP at 5 mug/L resulted in elevated point mutations of p53 gene in liver genome. The result suggests that TCP might be involved in carcinogenesis by inducing point mutations in somatic genome.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping