PUBLICATION
Genotoxic effect of 2,4,6-trichlorophenol on p53 gene in zebrafish liver
- Authors
- Yin, D., Zhu, H., Hu, P., and Zhao, Q.
- ID
- ZDB-PUB-081028-8
- Date
- 2009
- Source
- Environmental toxicology and chemistry 28(3): 603-608 (Journal)
- Registered Authors
- Zhao, Qingshun
- Keywords
- 2,4,6-Trichlorophenol, Zebrafish, p53 Gene, Point mutation, Genotoxicity
- MeSH Terms
-
- Animals
- Chlorophenols/toxicity*
- Liver/drug effects*
- Mutagens
- Point Mutation/drug effects
- Tumor Suppressor Protein p53/genetics*
- Zebrafish
- PubMed
- 18939895 Full text @ Environ. Toxicol. Chem.
- CTD
- 18939895
Citation
Yin, D., Zhu, H., Hu, P., and Zhao, Q. (2009) Genotoxic effect of 2,4,6-trichlorophenol on p53 gene in zebrafish liver. Environmental toxicology and chemistry. 28(3):603-608.
Abstract
The trichlorophenol (2,4,6-Trichlorophenol, TCP), a probable human carcinogen, is widely present in the environment. Employing denaturing high-performance liquid chromatography and DNA sequencing analyses, we demonstrated that 10 d exposure of zebrafish to TCP at 5 mug/L resulted in elevated point mutations of p53 gene in liver genome. The result suggests that TCP might be involved in carcinogenesis by inducing point mutations in somatic genome.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping