PUBLICATION
Mechanisms for reaching the differentiated state: Insights from neural crest-derived melanocytes
- Authors
- Cooper, C.D., and Raible, D.W.
- ID
- ZDB-PUB-081028-3
- Date
- 2009
- Source
- Seminars in cell & developmental biology 20(1): 105-110 (Review)
- Registered Authors
- Raible, David
- Keywords
- melanocytes, differentiation, neural crest, specification
- MeSH Terms
-
- Neural Crest/cytology*
- Animals
- Humans
- Sensitivity and Specificity
- Cell Differentiation*
- Melanocytes/cytology*
- PubMed
- 18935965 Full text @ Sem. Cell Dev. Biol.
Citation
Cooper, C.D., and Raible, D.W. (2009) Mechanisms for reaching the differentiated state: Insights from neural crest-derived melanocytes. Seminars in cell & developmental biology. 20(1):105-110.
Abstract
Black pigment cells, or melanocytes, are the major contributing cells to pigmentation in vertebrate organisms. Although the function of these cells is distinct depending on the organism, the events involved in their development are remarkably similar. Here, we review the mechanisms involved in the early development of melanocytes from neural crest, many of which are conserved in organisms as diverse as zebrafish, birds and humans. We also discuss recent studies that provide further insight into how melanocyte differentiation is achieved and maintained.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping