ZFIN ID: ZDB-PUB-080825-3
A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia
England, S.J., Blanchard, G.B., Mahadevan, L., and Adams, R.J.
Date: 2006
Source: Development (Cambridge, England)   133(23): 4613-4617 (Journal)
Registered Authors: Adams, Richard
Keywords: Zebrafish, Time-lapse microscopy, Neurulation, Cyclopia, Quantitative analyses
MeSH Terms:
  • Animals
  • Eye Abnormalities/embryology*
  • Eye Abnormalities/genetics
  • Intracellular Signaling Peptides and Proteins/genetics
  • Mutation
  • Prosencephalon/embryology*
  • Wnt Proteins/genetics
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics
PubMed: 17079266 Full text @ Development
Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while evaginating two eyes from a single contiguous domain within the neural plate. We, for the first time, track these cell rearrangements to show that forebrain morphogenesis differs significantly from prior hypotheses. We postulate a new model for forebrain neurulation and demonstrate how mutations affecting two signalling pathways can generate cyclopic phenotypes by disrupting normal cell movements or introducing new erroneous behaviours.