ZFIN ID: ZDB-PUB-080801-16
Cadherin-7 function in zebrafish development
Liu, Q., Marrs, J.A., Londraville, R.L., and Wilson, A.L.
Date: 2008
Source: Cell and tissue research   334(1): 37-45 (Journal)
Registered Authors: Liu, Qin, Marrs, James A.
Keywords: Cell adhesion molecules, Notochord, Central nervous system, Antisense morpholino oligonucleotides, Zebrafish, Danio rerio (Teleostei)
MeSH Terms:
  • Animals
  • Biomarkers/metabolism
  • Cadherins/genetics
  • Cadherins/physiology*
  • Central Nervous System/drug effects
  • Central Nervous System/embryology*
  • Embryo, Nonmammalian/drug effects
  • Embryo, Nonmammalian/physiology
  • Gene Expression Regulation, Developmental
  • Notochord/cytology
  • Notochord/drug effects
  • Notochord/physiology*
  • Oligonucleotides, Antisense/genetics
  • Zebrafish/embryology*
  • Zebrafish/physiology
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology*
PubMed: 18665394 Full text @ Cell Tissue Res.
Cadherin cell adhesion molecules play crucial roles in vertebrate development. Most studies have focused on examining the functions of classical type I cadherins (e.g., cadherin-2) in the development of vertebrates. Little information is available concerning the function of classical type II cadherins (e.g., cadherin-7) in vertebrate development. We have previously shown that cadherin-7 mRNA exhibits a dynamic expression pattern in the central nervous system and notochord in embryonic zebrafish. To gain insight into the role of cadherin-7 in the formation of these structures, we analyzed their formation in zebrafish embryos injected with cadherin-7-specific antisense morpholino oligonucleotides (MO). Notochord development was severely disrupted in MO-injected embryos, whereas gross defects in the development of the central nervous system were not detected in MO-injected embryos. Our results thus demonstrate that cadherin-7 plays an important role in the normal development of the zebrafish notochord.