PUBLICATION
FGF-Dependent Mechanosensory Organ Patterning in Zebrafish
- Authors
- Nechiporuk, A., and Raible, D.W.
- ID
- ZDB-PUB-080630-20
- Date
- 2008
- Source
- Science (New York, N.Y.) 320(5884): 1774-1777 (Journal)
- Registered Authors
- Nechiporuk, Alex, Raible, David
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Body Patterning*
- Cell Differentiation
- Cell Polarity
- Embryo, Nonmammalian/metabolism*
- Embryonic Development
- Fibroblast Growth Factor 10/genetics
- Fibroblast Growth Factor 10/metabolism*
- Fibroblast Growth Factor 3/genetics
- Fibroblast Growth Factor 3/metabolism*
- Gene Expression Regulation, Developmental
- Lateral Line System/cytology
- Lateral Line System/embryology*
- Lateral Line System/metabolism
- Mechanoreceptors/cytology
- Mechanoreceptors/embryology*
- Mechanoreceptors/metabolism
- Pyrroles/pharmacology
- Receptors, Fibroblast Growth Factor/antagonists & inhibitors
- Signal Transduction
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 18583612 Full text @ Science
Citation
Nechiporuk, A., and Raible, D.W. (2008) FGF-Dependent Mechanosensory Organ Patterning in Zebrafish. Science (New York, N.Y.). 320(5884):1774-1777.
Abstract
During development, organ primordia reorganize to form repeated functional units. In zebrafish (Danio rerio), mechanosensory organs called neuromasts are deposited at regular intervals by the migrating posterior lateral line (pLL) primordium. The pLL primordium is organized into polarized rosettes representing proto-neuromasts, each with a central atoh1a-positive focus of mechanosensory precursors. We show that rosettes form cyclically from a progenitor pool at the leading zone of the primordium as neuromasts are deposited from the trailing region. fgf3/10 signals localized to the leading zone are required for rosette formation, atoh1a expression, and primordium migration. We propose that the fibroblast growth factor (FGF) source controls primordium organization, which, in turn, regulates the periodicity of neuromast deposition. This previously unrecognized mechanism may be applicable to understanding segmentation and morphogenesis in other organ systems.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping