PUBLICATION

Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA

Authors
Matthews, H.K., Marchant, L., Carmona-Fontaine, C., Kuriyama, S., Larraín, J., Holt, M.R., Parsons, M., and Mayor, R.
ID
ZDB-PUB-080415-10
Date
2008
Source
Development (Cambridge, England)   135(10): 1771-1780 (Journal)
Registered Authors
Mayor, Roberto
Keywords
Cell migration, Neural crest, Directionality, Persistence, Syndecan-4, Non-canonical Wnt signaling, PCP, RhoA, Rac1
MeSH Terms
  • Animals
  • Cell Movement/physiology
  • Cell Polarity/physiology
  • Embryo, Nonmammalian/physiology
  • Fluorescence Resonance Energy Transfer
  • Neural Crest/cytology*
  • Neural Crest/embryology
  • Neural Crest/metabolism
  • Signal Transduction
  • Syndecan-4/biosynthesis
  • Syndecan-4/physiology*
  • Wnt Proteins/physiology*
  • Xenopus
  • Zebrafish
  • cdc42 GTP-Binding Protein/metabolism
  • rac1 GTP-Binding Protein/physiology*
  • rhoA GTP-Binding Protein/physiology*
PubMed
18403410 Full text @ Development
Abstract
Directed cell migration is crucial for development, but most of our current knowledge is derived from in vitro studies. We analyzed how neural crest (NC) cells migrate in the direction of their target during embryonic development. We show that the proteoglycan Syndecan-4 (Syn4) is expressed in the migrating neural crest of Xenopus and zebrafish embryos. Loss-of-function studies using an antisense morpholino against syn4 show that this molecule is required for NC migration, but not for NC induction. Inhibition of Syn4 does not affect the velocity of cell migration, but significantly reduces the directional migration of NC cells. Furthermore, we show that Syn4 and PCP signaling control the directional mfor NC migration, but not for NC induction. Inhibition of Syn4 does not affect the velocity of cell migration, but significantly reduces the direigration of NC cells by regulating the direction in which the cell protrusions are generated during migration. Finally, we perform FRET analysis of Cdc42, Rac and RhoA in vitro and in vivo after interfering with Syn4 and PCP signaling. This is the first time that FRET analysis of small GTPases has been performed in vivo. Our results show that Syn4 inhibits Rac activity, whereas PCP signaling promotes RhoA activity. In addition, we show that RhoA inhibits Rac in NC cells. We present a model in which Syn4 and PCP control directional NC migration by, at least in part, regulating membrane protrusions through the regulation of small GTPase activities.
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