PUBLICATION

Differential expression of duplicated genes for prothymosin alpha during zebrafish development

Authors
Donizetti, A., Liccardo, D., Esposito, D., Del Gaudio, R., Locascio, A., Ferrara, D., Minucci, S., and Aniello, F.
ID
ZDB-PUB-080324-8
Date
2008
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   237(4): 1112-1118 (Journal)
Registered Authors
Aniello, Francesco, Donizetti, Aldo, Liccardo, Daniela
Keywords
ptma, gene duplication, zebrafish embryo, central nervous system, eye, placode, pronephric ducts, endodermal pouches
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Gene Duplication*
  • Gene Expression Regulation, Developmental*
  • Humans
  • In Situ Hybridization
  • Molecular Sequence Data
  • Phylogeny
  • Protein Isoforms/classification
  • Protein Isoforms/genetics*
  • Protein Isoforms/metabolism
  • Protein Precursors/classification
  • Protein Precursors/genetics*
  • Protein Precursors/metabolism
  • Sequence Alignment
  • Thymosin/analogs & derivatives*
  • Thymosin/classification
  • Thymosin/genetics
  • Thymosin/metabolism
  • Zebrafish/anatomy & histology
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Zebrafish Proteins/classification
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
PubMed
18351673 Full text @ Dev. Dyn.
Abstract
We show that ptma, a single copy gene found in all organisms investigated so far, is duplicated in zebrafish. The two genes, ptmaa and ptmab, are individually controlled as indicated by their different expression patterns during embryonic development. Only the ptmab transcript is observed at 4 and 8 hpf of development in all embryonic cells, whereas both genes are expressed at later stages as revealed by in situ hybridization studies. In most cases, the two genes are expressed in the same territories, but only the ptmaa transcript was found in the trigeminal ganglion and in endodermal pouches. In the eye, at 72 hpf, the ptmaa and ptmab transcripts were found in amacrine cells, whereas only the ptmab transcript appeared in horizontal cells. The existence of two prothymosin genes indicates that their function in cell proliferation and differentiation is more complex in fishes than in mammals.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping