PUBLICATION
Clearing the path for germ cells
- Authors
- Knaut, H., and Schier, A.F.
- ID
- ZDB-PUB-080309-7
- Date
- 2008
- Source
- Cell 132(3): 337-339 (Journal)
- Registered Authors
- Knaut, Holger, Schier, Alexander
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Movement*
- Models, Biological
- Embryo, Nonmammalian/metabolism
- Germ Cells/cytology*
- Zebrafish/embryology
- PubMed
- 18267065 Full text @ Cell
Citation
Knaut, H., and Schier, A.F. (2008) Clearing the path for germ cells. Cell. 132(3):337-339.
Abstract
The chemokine SDF-1a and its receptor CXCR4b guide germ cell migration in zebrafish by activating downstream signaling events. Boldajipour et al. (2008) now report that a second SDF-1a receptor, CXCR7, is also required for guided migration but does not function as a signaling receptor, and instead sequesters SDF-1a. These results highlight the importance of ligand clearance during guided cell migration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping