ZFIN ID: ZDB-PUB-080306-22
Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
Tobin, D.M., and Ramakrishnan, L.
Date: 2008
Source: Cellular Microbiology   10(5): 1027-1039 (Review)
Registered Authors: Ramakrishnan, Lalita, Tobin, David
Keywords: none
MeSH Terms:
  • Animals
  • Host-Pathogen Interactions
  • Humans
  • Mycobacterium Infections/microbiology*
  • Mycobacterium marinum/genetics
  • Mycobacterium marinum/immunology
  • Mycobacterium marinum/pathogenicity*
  • Mycobacterium tuberculosis/genetics
  • Mycobacterium tuberculosis/immunology
  • Mycobacterium tuberculosis/pathogenicity*
  • Zebrafish
PubMed: 18298637 Full text @ Cell. Microbiol.
A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has been elusive in part because of imperfect surrogate laboratory hosts, each with its own idiosyncrasies. Mycobacterium marinum is the closest genetic relative of the Mycobacterium tuberculosis complex and is a natural pathogen of ectotherms. In this review, we present evidence that the similar genetic programs of M. marinum and M. tuberculosis and the corresponding host immune responses reveal a conserved skeleton of Mycobacterium host-pathogen interactions. While both species have made niche-specific refinements, an essential framework has persisted. We highlight genetic comparisons of the two organisms and studies of M. marinum in the developing zebrafish. By pairing M. marinum with the simplified immune system of zebrafish embryos, many of the defining mechanisms of mycobacterial pathogenesis can be distilled and investigated in a tractable host/pathogen pair.