ZFIN ID: ZDB-PUB-080226-9
Expression of the eight AMPA receptor subunit genes in the developing central nervous system and sensory organs of zebrafish
Hoppmann, V., Wu, J.J., Søviknes, A.M., Helvik, J.V., and Becker, T.S.
Date: 2008
Source: Developmental dynamics : an official publication of the American Association of Anatomists   237(3): 788-799 (Journal)
Registered Authors: Becker, Thomas S.
Keywords: teleost whole genome duplication, GluR, AMPAR
MeSH Terms:
  • Animals
  • Central Nervous System/cytology
  • Central Nervous System/embryology*
  • Central Nervous System/metabolism*
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/embryology
  • Embryo, Nonmammalian/metabolism*
  • Embryonic Development
  • Gene Expression Regulation, Developmental
  • Receptors, AMPA/genetics
  • Receptors, AMPA/metabolism*
  • Retina/embryology*
  • Retina/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
PubMed: 18224707 Full text @ Dev. Dyn.
The AMPA type glutamate receptors mediate the majority of fast synaptic transmission in the vertebrate nervous system. Whereas mammals have four subunit genes, Gria1-4, zebrafish has retained a duplicated set of eight genes named gria1-4a and b. We give here a detailed overview of the expression patterns of all eight zebrafish subunits within the developing central nervous system and sensory organs at 24, 48, and 72 hr after fertilization. Expression domains include distinct neuronal subsets in the developing forebrain, midbrain, hindbrain, and spinal cord, as well as in the ganglion- and inner nuclear layers of the retina. As a general rule, each pair of duplicated gria genes is differentially expressed, indicating subfunctionalization of AMPA receptor subunit expression in the teleost lineage. Our findings suggest that zebrafish can serve as a useful model system to investigate the role of AMPA receptors and their differential expression in the vertebrate nervous system.