PUBLICATION
Alkaline phosphatase: keeping the peace at the gut epithelial surface
- Authors
- Vaishnava, S., and Hooper, L.V.
- ID
- ZDB-PUB-071219-21
- Date
- 2007
- Source
- Cell Host & Microbe 2(6): 365-367 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Alkaline Phosphatase/physiology*
- Animals
- Bacterial Physiological Phenomena
- Homeostasis
- Humans
- Intestinal Mucosa/microbiology*
- Intestinal Mucosa/physiology*
- Lipopolysaccharides/metabolism
- Microvilli/enzymology
- PubMed
- 18078687 Full text @ Cell Host Microbe
Citation
Vaishnava, S., and Hooper, L.V. (2007) Alkaline phosphatase: keeping the peace at the gut epithelial surface. Cell Host & Microbe. 2(6):365-367.
Abstract
Vertebrate intestinal surfaces are in constant contact with a vast consortium of commensal bacteria. To preserve mutually beneficial host-microbial relationships, gut epithelia have evolved strategies to limit the proinflammatory potential of resident gut microbes. In this issue of Cell Host & Microbe, Bates and colleagues report that intestinal alkaline phosphatase, whose expression is induced during establishment of the microbiota, dephosphorylates lipopolysaccharide and promotes mucosal tolerance to commensal bacteria in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping