ZFIN ID: ZDB-PUB-071001-1
Zebrafish (Danio rerio) Genome and Genetics
Dahm, R., Geisler, R., and Nüsslein-Volhard, C.
Owing to its transparent, easily accessible embryos, simple breeding, and short generation time, the zebrafish has become one of the most important model organisms to study the genetic control of embryonic development. Zebrafish research initially focused on forward genetics (mutagenesis screening), but reverse genetic methods, transgenesis, and microarrays are now equally available to characterize known genes. The zebrafish genome consists of 25 chromosome pairs and has an estimated haploid size of 1.5 Gb. Several genome maps exist for the zebrafish. The meiotic MGH map is generally used for placement of mutant loci and, in combination with the T51 radiation hybrid map and BAC fingerprinting, forms the basis of genome sequencing. A genome sequence is being generated by a combination of whole-genome shotgun and BAC-based sequencing, and is expected to be finished in 2005.
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