PUBLICATION
Expression of multiple class three semaphorins in the retina and along the path of zebrafish retinal axons
- Authors
- Callander, D.C., Lamont, R.E., Childs, S.J., and McFarlane, S.
- ID
- ZDB-PUB-070920-27
- Date
- 2007
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 236(10): 2918-2924 (Journal)
- Registered Authors
- Childs, Sarah J., Lamont, Ryan
- Keywords
- Sema3, visual system, diencephalon, optic tectum, axon guidance
- MeSH Terms
-
- Animals
- Axons/ultrastructure*
- Diencephalon/embryology
- Diencephalon/metabolism
- Embryonic Development
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- In Situ Hybridization
- Optic Chiasm/embryology
- Optic Chiasm/metabolism
- Retina/embryology*
- Retina/metabolism
- Retinal Ganglion Cells/cytology*
- Semaphorins/genetics
- Semaphorins/metabolism*
- Superior Colliculi/embryology
- Superior Colliculi/metabolism
- Visual Pathways/embryology*
- Visual Pathways/metabolism
- Zebrafish
- PubMed
- 17879313 Full text @ Dev. Dyn.
Citation
Callander, D.C., Lamont, R.E., Childs, S.J., and McFarlane, S. (2007) Expression of multiple class three semaphorins in the retina and along the path of zebrafish retinal axons. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(10):2918-2924.
Abstract
Retinal ganglion cells (RGCs) extend axons that exit the eye, cross the midline at the optic chiasm, and synapse on target cells in the optic tectum. Class three semaphorins (Sema3s) are a family of molecules known to direct axon growth. We undertook an expression screen to identify sema3s expressed in the retina and/or brain close to in-growing RGC axons, which might therefore influence retinal-tectal pathfinding. We find that sema3Aa, 3Fa, 3Ga, and 3Gb are expressed in the retina, although only sema3Fa is present during the time window when the axons extend. Also, we show that sema3Aa and sema3E are present near or at the optic chiasm. Furthermore, sema3C, 3Fa, 3Ga, and 3Gb are expressed in regions of the diencephalon near the path taken by RGC axons. Finally, the optic tectum expresses sema3Aa, 3Fa, 3Fb, and 3Gb. Thus, sema3s are spatiotemporally placed to influence RGC axon growth.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping