PUBLICATION

Expression of multiple class three semaphorins in the retina and along the path of zebrafish retinal axons

Authors
Callander, D.C., Lamont, R.E., Childs, S.J., and McFarlane, S.
ID
ZDB-PUB-070920-27
Date
2007
Source
Developmental dynamics : an official publication of the American Association of Anatomists   236(10): 2918-2924 (Journal)
Registered Authors
Childs, Sarah J., Lamont, Ryan
Keywords
Sema3, visual system, diencephalon, optic tectum, axon guidance
MeSH Terms
  • Animals
  • Axons/ultrastructure*
  • Diencephalon/embryology
  • Diencephalon/metabolism
  • Embryonic Development
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • In Situ Hybridization
  • Optic Chiasm/embryology
  • Optic Chiasm/metabolism
  • Retina/embryology*
  • Retina/metabolism
  • Retinal Ganglion Cells/cytology*
  • Semaphorins/genetics
  • Semaphorins/metabolism*
  • Superior Colliculi/embryology
  • Superior Colliculi/metabolism
  • Visual Pathways/embryology*
  • Visual Pathways/metabolism
  • Zebrafish
PubMed
17879313 Full text @ Dev. Dyn.
Abstract
Retinal ganglion cells (RGCs) extend axons that exit the eye, cross the midline at the optic chiasm, and synapse on target cells in the optic tectum. Class three semaphorins (Sema3s) are a family of molecules known to direct axon growth. We undertook an expression screen to identify sema3s expressed in the retina and/or brain close to in-growing RGC axons, which might therefore influence retinal-tectal pathfinding. We find that sema3Aa, 3Fa, 3Ga, and 3Gb are expressed in the retina, although only sema3Fa is present during the time window when the axons extend. Also, we show that sema3Aa and sema3E are present near or at the optic chiasm. Furthermore, sema3C, 3Fa, 3Ga, and 3Gb are expressed in regions of the diencephalon near the path taken by RGC axons. Finally, the optic tectum expresses sema3Aa, 3Fa, 3Fb, and 3Gb. Thus, sema3s are spatiotemporally placed to influence RGC axon growth.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes