PUBLICATION

Four twist genes in zebrafish, four expression patterns

Authors
Germanguz, I., Lev, D., Waisman, T., Kim, C.H., and Gitelman, I.
ID
ZDB-PUB-070813-17
Date
2007
Source
Developmental dynamics : an official publication of the American Association of Anatomists   236(9): 2615-2626 (Journal)
Registered Authors
Kim, Cheol-Hee
Keywords
zebrafish, embryo, development, in situ, mRNA, expression, pattern, twist, gene family evolution, protein, limb bud cranial, cephalic neural crest, limb bud
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Body Patterning
  • Developmental Biology/methods*
  • Gene Expression Regulation, Developmental*
  • Humans
  • Limb Buds/embryology
  • Mesoderm/metabolism
  • Molecular Sequence Data
  • Neural Crest/embryology
  • Phylogeny
  • RNA, Messenger/metabolism
  • Sequence Homology, Amino Acid
  • Twist-Related Protein 1/biosynthesis*
  • Twist-Related Protein 1/physiology
  • Zebrafish
PubMed
17685477 Full text @ Dev. Dyn.
Abstract
Twist genes code for regulatory bHLH proteins essential for embryonic development and conserved across the metazoa. There are four genes that constitute the zebrafish twist family: twist1a, twist1b, twist2, orthologs of the mammalian twist1 and twist2 genes; and twist3-a gene from a new clade that does not exist in mammals. Presented here are their embryonic mRNA expression profiles. The study extends the known conservation of twist developmental patterns in tetrapods to the fish, e.g., expression in cephalic neural crest, sclerotome and lateral plate mesoderm. Some other expression domains are unique, like hypochord and dorsal aorta; some, like the notochord, may be ancestral patterns retained from protochordates; and the expression in invaginating/migrating cells may have been retained from the jellyfish. Perhaps this is one of the more ancient functions of twist-conserved from diploblasts to humans-to facilitate cell movement.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes