PUBLICATION
Expression patterns of alternative transcripts of the zebrafish olfactomedin 1 genes
- Authors
- Nakaya, N., and Tomarev, S.
- ID
- ZDB-PUB-070813-13
- Date
- 2007
- Source
- Gene expression patterns : GEP 7(7): 723-729 (Journal)
- Registered Authors
- Keywords
- Olfactomedin, Zebrafish, Development, In situ hybridization, Motor neurons, Rohon-Beard neurons, Trigeminal ganglia, Neural crest
- MeSH Terms
-
- Sequence Homology, Amino Acid
- Neural Crest/metabolism
- Alternative Splicing
- Gene Expression Regulation, Developmental
- Xenopus
- Zebrafish
- Gene Expression Profiling*
- Mice
- Animals
- Extracellular Matrix Proteins/biosynthesis*
- Trigeminal Ganglion/metabolism
- Molecular Sequence Data
- Gene Expression Regulation
- Glycoproteins/biosynthesis*
- Amino Acid Sequence
- Neurons/metabolism*
- PubMed
- 17681890 Full text @ Gene Expr. Patterns
Citation
Nakaya, N., and Tomarev, S. (2007) Expression patterns of alternative transcripts of the zebrafish olfactomedin 1 genes. Gene expression patterns : GEP. 7(7):723-729.
Abstract
Olfactomedin 1 (Olfm1) is a founding member of the family of olfactomedin domain-containing proteins. It is a secreted protein that performs different roles in different species. Although the molecular mechanisms of Olfm1 action are not known, its possible roles include the regulation of neural crest cell production, neuronal differentiation, and ischemic neuronal death in adult. Two zebrafish olfm1 genes (olfm1a and olfm1b) located on chromosomes 5 and 21 were identified in zebrafish genome. Four different transcripts are produced from each olfm1 gene. The distribution of these transcripts in the course of zebrafish early development was studied by in situ hybridization and quantitative RT-PCR. Different variants of olfm1 mRNA were present mainly in neurogenic tissues and demonstrated overlapping expression patterns.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping