|ZFIN ID: ZDB-PUB-070629-8|
Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors
Goessling, W., North, T.E., and Zon, L.I.
|Source:||Nature Methods 4(7): 551-553 (Journal)|
|Registered Authors:||Goessling, Wolfram, North, Trista, Zon, Leonard I.|
|PubMed:||17572681 Full text @ Nat. Methods|
Goessling, W., North, T.E., and Zon, L.I. (2007) Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors. Nature Methods. 4(7):551-553.
ABSTRACTZebrafish are a valuable vertebrate model to study carcinogenesis, but noninvasive imaging is challenging because adult fish are not transparent. Here we show that tumors could be readily detected in vivo using high-resolution microscopic ultrasound in zebrafish. We successfully obtained tissue perfusion calculations and cellular aspirates, and analyzed tumor progression and response to treatment. Ultrasound biomicroscopy allows longitudinal studies of tumor development and real-time assessment of therapeutic effects in zebrafish.
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