PUBLICATION
Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases
- Authors
- Xie, J., Bessling, S.L., Cooper, T.K., Dietz, H.C., McCallion, A.S., and Fisher, S.
- ID
- ZDB-PUB-070513-16
- Date
- 2007
- Source
- Genetics 176(2): 1339-1342 (Journal)
- Registered Authors
- Fisher, Shannon, McCallion, Andy
- Keywords
- RecQ helicase, blm, mitotic recombination, recql5, zebrafish
- MeSH Terms
-
- Transcription, Genetic
- Sequence Alignment
- Werner Syndrome/genetics
- Sequence Homology, Amino Acid
- Amino Acid Sequence
- RNA/genetics
- Recombination, Genetic*
- Animals
- Mitosis*
- RecQ Helicases/genetics*
- Zebrafish/embryology*
- Zebrafish/genetics
- Bloom Syndrome/genetics
- Molecular Sequence Data
- Embryo, Nonmammalian/physiology*
- Zebrafish Proteins/genetics*
- Mutation
- PubMed
- 17483412 Full text @ Genetics
Citation
Xie, J., Bessling, S.L., Cooper, T.K., Dietz, H.C., McCallion, A.S., and Fisher, S. (2007) Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Genetics. 176(2):1339-1342.
Abstract
RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping