ZFIN ID: ZDB-PUB-070513-16
Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases
Xie, J., Bessling, S.L., Cooper, T.K., Dietz, H.C., McCallion, A.S., and Fisher, S.
Date: 2007
Source: Genetics   176(2): 1339-1342 (Journal)
Registered Authors: Fisher, Shannon, McCallion, Andy
Keywords: RecQ helicase, blm, mitotic recombination, recql5, zebrafish
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Bloom Syndrome/genetics
  • Embryo, Nonmammalian/physiology*
  • Mitosis*
  • Molecular Sequence Data
  • Mutation
  • RNA/genetics
  • RecQ Helicases/genetics*
  • Recombination, Genetic*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Transcription, Genetic
  • Werner Syndrome/genetics
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics*
PubMed: 17483412 Full text @ Genetics
RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.