PUBLICATION

Asymmetric innervation of the habenula in zebrafish

Authors
Hendricks, M., and Jesuthasan, S.
ID
ZDB-PUB-070409-3
Date
2007
Source
The Journal of comparative neurology   502(4): 611-619 (Journal)
Registered Authors
Hendricks, Michael, Jesuthasan, Suresh
Keywords
habenula afferent, asymmetry, eminentia thalami, pallium, habenula commissure, neuropil
MeSH Terms
  • Afferent Pathways/anatomy & histology*
  • Afferent Pathways/physiology
  • Animals
  • Axons/physiology
  • Axons/ultrastructure*
  • Brain Mapping
  • Carbocyanines
  • Diencephalon/anatomy & histology
  • Diencephalon/physiology
  • Functional Laterality/physiology
  • Habenula/anatomy & histology*
  • Habenula/physiology
  • Telencephalon/anatomy & histology
  • Telencephalon/physiology
  • Zebrafish/anatomy & histology*
  • Zebrafish/physiology
(all 16)
PubMed
17394162 Full text @ J. Comp. Neurol.
Abstract
The habenular complex is a paired structure found in the diencephalon of all vertebrates, linking the forebrain and midbrain. Habenulae are asymmetrical and may contribute to lateralized behavior. Recent studies in zebrafish have characterized molecular pathways that give rise to the habenular asymmetry and the distinct projections of the left and right habenula to the midbrain. However, it is unclear whether there are asymmetries in habenula afferents from the forebrain. By lipophilic dye tracing, we find that axons innervating the habenula derive primarily from a region in the lateral diencephalon containing migrated neurons of the eminentia thalami (EmT). EmT neurons terminate in neuropils in both ipsilateral and contralateral habenula. These axons, together with axons from migrated neurons of the posterior tuberculum and pallial neurons, cross the midline via the habenular commissure. Subsets of pallial neurons terminate only in the medial right habenula, regardless of which side of the brain they originate from. These include an unusual type of forebrain projection: axons that cross the midline twice, at both the anterior and habenular commissures. Our data establish that there is asymmetric innervation of the habenula from the telencephalon, suggesting a mechanism by which habenula asymmetry might contribute to lateralized behavior.
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Mutations / Transgenics
Allele Construct Type Affected Genomic Region
kca2TgTransgenic Insertion
    rk8TgTransgenic Insertion
      rw0110bTgTransgenic Insertion
        rw0130aTgTransgenic Insertion
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          Engineered Foreign Genes
          Marker Marker Type Name
          GAL4EFGGAL4
          GFPEFGGFP
          KaedeEFGKaede
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