PUBLICATION
An ancient chordin-like gene in organizer formation of Hydra
- Authors
- Rentzsch, F., Guder, C., Vocke, D., Hobmayer, B., and Holstein, T.W.
- ID
- ZDB-PUB-070330-9
- Date
- 2007
- Source
- Proceedings of the National Academy of Sciences of the United States of America 104(9): 3249-3254 (Journal)
- Registered Authors
- Rentzsch, Fabian
- Keywords
- axis formation, bone morphogenetic protein/Chordin, Cnidaria, regeneration, signaling
- MeSH Terms
-
- Bone Morphogenetic Proteins/antagonists & inhibitors
- Intercellular Signaling Peptides and Proteins/genetics*
- Intercellular Signaling Peptides and Proteins/pharmacology
- Hydra/embryology*
- Hydra/genetics*
- Cloning, Molecular
- Zebrafish/embryology*
- Zebrafish/metabolism
- Embryo, Nonmammalian/metabolism*
- Mutation/genetics
- Biological Evolution
- Glycoproteins/genetics*
- Glycoproteins/pharmacology
- In Situ Hybridization
- Gene Expression Regulation, Developmental*
- Organizers, Embryonic/physiology
- Animals
- Signal Transduction/genetics
- Signal Transduction/physiology
- Body Patterning/genetics*
- Body Patterning/physiology
- Microinjections
- DNA Primers
- PubMed
- 17360633 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Rentzsch, F., Guder, C., Vocke, D., Hobmayer, B., and Holstein, T.W. (2007) An ancient chordin-like gene in organizer formation of Hydra. Proceedings of the National Academy of Sciences of the United States of America. 104(9):3249-3254.
Abstract
Signaling centers or organizers play a key role in axial patterning processes in animal embryogenesis. The function of most vertebrate organizers involves the activity of secreted antagonists of bone morphogenetic proteins (BMPs) such as Chordin or Noggin. Although BMP homologs have been isolated from many phyla, the evolutionary origin of the antagonistic BMP/Chordin system in organizer signaling is presently unknown. Here we describe a Chordin-like molecule (HyChdl) from Hydra that inhibits BMP activity in zebrafish embryos and acts in Hydra axis formation when new head organizers are formed during budding and regeneration. hychdl transcripts are also up-regulated in the head regeneration-deficient mutant strain reg-16. Accordingly, HyChdl has a function in organizer formation, but not in head differentiation. Our data indicate that the BMP/Chordin antagonism is a basic property of metazoan signaling centers that was invented in early metazoan evolution to set up axial polarity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping