PUBLICATION
The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines
- Authors
- Meiniel, A., Meiniel, R., Goncalves-Mendes, N., Creveaux, I., Didier, R., and Dastugue, B.
- ID
- ZDB-PUB-070330-48
- Date
- 2003
- Source
- International review of cytology 230(1): 1-39 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Cell Differentiation/physiology*
- Protein Structure, Tertiary
- Evolution, Molecular
- Cell Adhesion Molecules, Neuronal/classification
- Cell Adhesion Molecules, Neuronal/genetics
- Cell Adhesion Molecules, Neuronal/metabolism*
- Multigene Family
- Thrombospondin 1/classification
- Thrombospondin 1/genetics*
- Thrombospondin 1/metabolism
- Animals
- Subcommissural Organ/cytology
- Subcommissural Organ/growth & development*
- Subcommissural Organ/metabolism
- Integrins/metabolism
- Humans
- Molecular Sequence Data
- Oligopeptides/metabolism*
- Cell Line
- Amino Acid Sequence*
- Neurons/cytology
- Neurons/physiology*
- Phylogeny
- Receptors, Growth Factor/metabolism
- PubMed
- 14692680 Full text @ Int. Rev. Cytol.
Citation
Meiniel, A., Meiniel, R., Goncalves-Mendes, N., Creveaux, I., Didier, R., and Dastugue, B. (2003) The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines. International review of cytology. 230(1):1-39.
Abstract
SCO-spondin is a large glycoprotein secreted by ependymal cells of the subcommissural organ. It shares functional domains called thrombospondin type 1 repeats (TSRs) with a number of developmental proteins expressed in the central nervous system, and involved in axonal pathfinding. Also, SCO-spondin is highly conserved in the chordate phylum and its multiple domain organization is probably a chordate innovation. The putative involvement of SCO-spondin in neuron/glia interaction in the course of development is assessed in various cell culture systems. SCO-spondin interferes with several developmental processes, including neuronal survival, neurite extension, neuronal aggregation, and fasciculation. The TSR motifs, and especially the WSGWSSCSVSCG sequence, are most important in these neuronal responses. Integrins and growth factor receptors may cooperate as integrative signals. We discuss the putative involvement of the subcommissural organ/Reissner's fiber complex in developmental events, as a particular extracellular signaling system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping