PUBLICATION
Apelin and its G protein-coupled receptor regulate cardiac development as well as cardiac function
- Authors
- Quertermous, T.
- ID
- ZDB-PUB-070310-6
- Date
- 2007
- Source
- Developmental Cell 12(3): 319-320 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Intercellular Signaling Peptides and Proteins/metabolism*
- Receptors, G-Protein-Coupled/metabolism*
- Cell Differentiation/physiology
- Cell Lineage/physiology
- Animals
- Myocytes, Cardiac/cytology
- Myocytes, Cardiac/metabolism*
- Heart/embryology*
- Heart/physiology
- Cell Movement/physiology
- Humans
- Zebrafish/embryology
- Zebrafish/metabolism
- Myoblasts, Cardiac/cytology
- Myoblasts, Cardiac/metabolism
- PubMed
- 17336895 Full text @ Dev. Cell
Citation
Quertermous, T. (2007) Apelin and its G protein-coupled receptor regulate cardiac development as well as cardiac function. Developmental Cell. 12(3):319-320.
Abstract
The Apelin pathway has only recently emerged as an important regulator of cardiac and vascular function, mediating adaptation to physiological stress and disease. In this issue of Developmental Cell, experiments in zebrafish convincingly show a critical role for this pathway in myocardial cell specification and heart development (Scott et al., 2007; Zeng et al., 2007).
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping