PUBLICATION
Quantifying cardiovascular flow dynamics during early development
- Authors
- Hove, J.R.
- ID
- ZDB-PUB-070212-6
- Date
- 2006
- Source
- Pediatric Research 60(1): 6-13 (Review)
- Registered Authors
- Hove, Jay R.
- Keywords
- none
- MeSH Terms
-
- Animals
- Blood Circulation/physiology*
- Blood Flow Velocity/physiology
- Cardiovascular Physiological Phenomena*
- Cardiovascular System/embryology*
- Hemodynamics/physiology
- Regional Blood Flow/physiology
- Rheology
- Zebrafish
- PubMed
- 16690955 Full text @ Pediatr. Res.
Citation
Hove, J.R. (2006) Quantifying cardiovascular flow dynamics during early development. Pediatric Research. 60(1):6-13.
Abstract
The relationship between developing biologic tissues and their dynamic fluid environments is intimate and complex. Increasing evidence supports the notion that these embryonic flow-structure interactions influence whether development will proceed normally or become pathogenic. Genetic, pharmacological, or surgical manipulations that alter the flow environment can thus profoundly influence morphologic and functional cardiovascular phenotypes. Functionally deficient phenotypes are particularly poorly described as there are few imaging tools with sufficient spatial and temporal resolution to quantify most intra-vital flows. The ability to visualize biofluids flow in vivo would be of great utility in functionally phenotyping model animal systems and for the elucidation of the mechanisms that underlie flow-related mechano-sensation and transduction in living organisms. This review summarizes the major methodological advances that have evolved for the quantitative characterization of intra-vital fluid dynamics with an emphasis on assessing cardiovascular flows in vertebrate model organisms.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping