PUBLICATION
Copper deficiency
- Authors
- Madsen, E., and Gitlin, J.D.
- ID
- ZDB-PUB-070212-19
- Date
- 2007
- Source
- Current opinion in gastroenterology 23(2): 187-192 (Review)
- Registered Authors
- Gitlin, Jonathan D.
- Keywords
- none
- MeSH Terms
-
- Animals
- Biological Transport/genetics
- Carrier Proteins/genetics
- Carrier Proteins/physiology
- Cation Transport Proteins/genetics
- Central Nervous System Diseases/etiology*
- Central Nervous System Diseases/genetics
- Copper/analysis
- Copper/deficiency*
- Copper/metabolism
- Disease Models, Animal
- Humans
- Menkes Kinky Hair Syndrome/etiology*
- Menkes Kinky Hair Syndrome/genetics
- Mice
- Mitochondria/chemistry
- Mitochondria/metabolism
- Mitochondrial Proteins/genetics
- Mitochondrial Proteins/physiology
- PubMed
- 17268249 Full text @ Curr. Opin. Gastroenterol.
- CTD
- 17268249
Citation
Madsen, E., and Gitlin, J.D. (2007) Copper deficiency. Current opinion in gastroenterology. 23(2):187-192.
Abstract
PURPOSE OF REVIEW: Reports of the neurologic findings in adults with acquired copper deficiency as well as the development of novel models for Menkes disease have permitted a greater understanding of the role of copper in the central nervous system. A role of mitochondrial copper homeostasis in cellular energy metabolism suggests roles for this metal in cellular differentiation and biochemical adaptation. RECENT FINDINGS: Acquired copper deficiency in adults is reported with increasing frequency, often without any identifiable cause. Chemical genetic studies identified a zebrafish model of Menkes disease that can be used for high-throughput therapeutics and revealed a hierarchy of copper distribution during development. Studies in mice reveal that the copper transport protein Ctr1 is essential for intestinal copper absorption and suggest a unique role for copper in axonal extension, excitotoxic cell death and synaptic plasticity in the central nervous system. Lastly, recent biochemical studies indicate a central role for the mitochondrial matrix in cellular copper metabolism. SUMMARY: The recent developments in our understanding of copper deficiency and copper homeostasis outlined in this review provide an exciting platform for future investigations intended to elucidate the role of copper in central nervous system development and disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping