|ZFIN ID: ZDB-PUB-070210-17|
Small-molecule regulation of zebrafish gene expression
Esengil, H., Chang, V., Mich, J.K., and Chen, J.K.
|Source:||Nature Chemical Biology 3(3): 154-155 (Journal)|
|Registered Authors:||Chen, James K., Esengil, Hanife, Mich, John|
|PubMed:||17237798 Full text @ Nat. Chem. Biol.|
Esengil, H., Chang, V., Mich, J.K., and Chen, J.K. (2007) Small-molecule regulation of zebrafish gene expression. Nature Chemical Biology. 3(3):154-155.
ABSTRACTThe zebrafish has emerged as a versatile model organism for biomedical research, yet its potential has been limited by a lack of conditional reverse-genetic tools. Here we report a chemically inducible gene expression technology that has orthogonality to vertebrate signaling processes, high induction levels, and rapid kinetics. Coupled with tissue-specific promoters, this system provides multidimensional control of gene expression and will enable new models of human disorders and diseases.