ZFIN ID: ZDB-PUB-070210-17
Small-molecule regulation of zebrafish gene expression
Esengil, H., Chang, V., Mich, J.K., and Chen, J.K.
Date: 2007
Source: Nature Chemical Biology   3(3): 154-155 (Journal)
Registered Authors: Chen, James K., Esengil, Hanife, Mich, John
Keywords: none
MeSH Terms:
  • Animals
  • Cell Line
  • Embryo, Nonmammalian
  • Gene Expression Regulation/physiology*
  • Genomics/methods*
  • Herpes Simplex Virus Protein Vmw65/biosynthesis
  • Herpes Simplex Virus Protein Vmw65/genetics
  • Humans
  • Insecta
  • Receptors, Steroid/genetics
  • Receptors, Steroid/physiology
  • Trans-Activators/genetics
  • Zebrafish/genetics*
PubMed: 17237798 Full text @ Nat. Chem. Biol.
The zebrafish has emerged as a versatile model organism for biomedical research, yet its potential has been limited by a lack of conditional reverse-genetic tools. Here we report a chemically inducible gene expression technology that has orthogonality to vertebrate signaling processes, high induction levels, and rapid kinetics. Coupled with tissue-specific promoters, this system provides multidimensional control of gene expression and will enable new models of human disorders and diseases.