PUBLICATION
PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes
- Authors
- Lee, J.Y., Yeh, I.,. Park, J.Y., and Tian, B.
- ID
- ZDB-PUB-070203-5
- Date
- 2007
- Source
- Nucleic acids research 35: D165-8 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Internet
- Vertebrates/genetics*
- RNA, Messenger/chemistry*
- Humans
- Animals
- Rats
- Genomics
- Databases, Nucleic Acid*
- Poly A/analysis*
- RNA 3' Polyadenylation Signals*
- User-Computer Interface
- Synteny
- Polyadenylation*
- Mice
- PubMed
- 17202160 Full text @ Nucleic Acids Res.
Citation
Lee, J.Y., Yeh, I.,. Park, J.Y., and Tian, B. (2007) PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes. Nucleic acids research. 35:D165-8.
Abstract
Polyadenylation of nascent transcripts is one of the key mRNA processing events in eukaryotic cells. A large number of human and mouse genes have alternative polyadenylation sites, or poly(A) sites, leading to mRNA variants with different protein products and/or 3'-untranslated regions (3'-UTRs). PolyA_DB 2 contains poly(A) sites identified for genes in several vertebrate species, including human, mouse, rat, chicken and zebrafish, using alignments between cDNA/ESTs and genome sequences. Several new features have been added to the database since its last release, including syntenic genome regions for human poly(A) sites in seven other vertebrates and cis-element information adjacent to poly(A) sites. Trace sequences are used to provide additional evidence for poly(A/T) tails in cDNA/ESTs. The updated database is intended to broaden poly(A) site coverage in vertebrate genomes, and provide means to assess the authenticity of poly(A) sites identified by bioinformatics. The URL for this database is http://polya.umdnj.edu/PolyA_DB2.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping