ZFIN ID: ZDB-PUB-061229-6
PCR survey of hox genes in the goldfish Carassius auratus auratus
Luo, J., Stadler, P.F., He, S., and Meyer, A.
Date: 2007
Source: Journal of experimental zoology. Part B, Molecular and developmental evolution   308(3): 250-258 (Journal)
Registered Authors: Meyer, Axel
Keywords: none
MeSH Terms:
  • Animals
  • Base Sequence
  • DNA Primers
  • Genes, Homeobox/genetics*
  • Goldfish/genetics*
  • INDEL Mutation/genetics
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polyploidy*
  • Pseudogenes/genetics
  • Sequence Analysis, DNA
  • Species Specificity
PubMed: 17171698 Full text @ J. Exp. Zool. B Mol. Dev. Evol.
A tetraploidization event took place in the cyprinid lineage leading to goldfishes about 15 million years ago. A PCR survey for Hox genes in the goldfish Carassius auratus auratus (Actinopterygii: Cyprinidae) was performed to assess the consequences of this genome duplication. Not surprisingly, the genomic organization of the Hox gene clusters of goldfish is similar to that of the closely related zebrafish (Danio rerio). However, the goldfish exhibits a much larger number of recent pseudogenes, which are characterized by indels. These findings are consistent with the hypothesis that dosage effects cause selection pressure to rapidly silence crucial developmental regulators after a tetraploidization event.