PUBLICATION
Extracellular modulation of BMP activity in patterning the dorsoventral axis
- Authors
- Little, S.C., and Mullins, M.C.
- ID
- ZDB-PUB-061031-8
- Date
- 2006
- Source
- Birth defects research. Part C, Embryo today : reviews 78(3): 224-242 (Journal)
- Registered Authors
- Little, Shawn, Mullins, Mary C.
- Keywords
- none
- MeSH Terms
-
- Body Patterning*
- Drosophila melanogaster/embryology*
- Gene Expression Regulation, Developmental
- Xenopus Proteins/genetics
- Xenopus Proteins/metabolism
- Bone Morphogenetic Protein Receptors/metabolism*
- Signal Transduction
- Bone Morphogenetic Proteins/metabolism*
- Xenopus laevis/embryology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Zebrafish/embryology*
- Drosophila Proteins/genetics
- Drosophila Proteins/metabolism
- Embryo, Nonmammalian/metabolism
- Animals
- PubMed
- 17061292 Full text @ Birth Defects Res. C Embryo Today
Citation
Little, S.C., and Mullins, M.C. (2006) Extracellular modulation of BMP activity in patterning the dorsoventral axis. Birth defects research. Part C, Embryo today : reviews. 78(3):224-242.
Abstract
Signaling via bone morphogenetic proteins (BMPs) regulates a vast array of diverse biological processes in the developing embryo and in postembryonic life. Many insights into BMP signaling derive from studies of the BMP signaling gradients that pattern cell fates along the embryonic dorsal-ventral (DV) axis of both vertebrates and invertebrates. This review examines recent developments in the field of DV patterning by BMP signaling, focusing on extracellular modulation as a key mechanism in the formation of BMP signaling gradients in Drosophila, Xenopus, and zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping